| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| 100mg |
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| Other Sizes |
| Targets |
Phosphatidylglycerol does not have a defined pharmacological target. It is a structural lipid that plays a key role in membrane structure and function. It is the metabolic precursor of cardiolipin. It is widely used in research to study membrane dynamics, cell signaling, and lipid interactions.
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|---|---|
| ln Vitro |
In vitro, phosphatidylglycerols are used to study membrane dynamics, cell signaling, and lipid interactions. Phosphatidylglycerols containing polyunsaturated and monounsaturated fatty acyl chains inhibit and promote the proliferation of murine keratinocytes, respectively. It is also used in pharmaceutical and cosmetic formulations for its emulsifying properties.
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| ln Vivo |
In vivo, phosphatidylglycerol is a major component of lung surfactant and has reduced levels in infants with respiratory distress syndrome. It is a naturally occurring lipid found in biological membranes. Its role in vivo is structural and functional, contributing to membrane integrity and surfactant function.
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| Enzyme Assay |
For in vitro lipid assays, phosphatidylglycerols are used as a component of model membranes or as a substrate for lipid-modifying enzymes. Standard protocols involve preparing liposomes or lipid bilayers containing phosphatidylglycerol and studying their properties using techniques such as fluorescence spectroscopy, surface plasmon resonance, or microscopy. Cell proliferation assays using keratinocytes can be performed to study the effects of different fatty acyl compositions.
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| Cell Assay |
For in vitro cell-based experiments, phosphatidylglycerols can be added to cell culture media to study their effects on cell proliferation, signaling, or membrane dynamics. Cells such as keratinocytes are treated with phosphatidylglycerol preparations at various concentrations, and proliferation is assessed using standard assays.
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| Animal Protocol |
In vivo animal studies using phosphatidylglycerols are conducted to study lung surfactant function or lipid metabolism. Standard protocols involve administering phosphatidylglycerol preparations to animal models of respiratory distress syndrome or other lung conditions. Lung function, surfactant composition, and inflammatory markers are assessed.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of phosphatidylglycerols are not applicable as a therapeutic agent. As a natural lipid, it is metabolized and incorporated into membranes. When administered, it is expected to be processed through normal lipid metabolic pathways.
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| Toxicity/Toxicokinetics |
Phosphatidylglycerols are generally considered biocompatible and non-toxic as they are natural components of cell membranes. Standard laboratory safety practices should be followed when handling the compound.
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| References | |
| Additional Infomation |
Phosphatidylglycerols (egg) (sodium salt) (CAS 383907-64-0) is a research-grade lipid, not an FDA-approved pharmaceutical drug. Its primary applications are in membrane biology, cell signaling, and lipid interaction studies, as well as in pharmaceutical and cosmetic formulations for its emulsifying properties.
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| Molecular Formula |
C40H76NAO10P
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|---|---|
| Molecular Weight |
770.98898601532
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| Exact Mass |
268.032
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| CAS # |
383907-64-0
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| PubChem CID |
46891828
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| Appearance |
White to off-white solid powder
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
10
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| Rotatable Bond Count |
41
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| Heavy Atom Count |
52
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| Complexity |
875
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC(CO)O)OC(=O)CCCCCCC/C=C\CCCCCCCC.[Na+]
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| InChi Key |
FJXDNGDRHUDFST-XQYKCTAGSA-M
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| InChi Code |
InChI=1S/C40H77O10P.Na/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-40(44)50-38(36-49-51(45,46)48-34-37(42)33-41)35-47-39(43)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2;/h17-18,37-38,41-42H,3-16,19-36H2,1-2H3,(H,45,46);/q;+1/p-1/b18-17-;/t37?,38-;/m1./s1
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| Chemical Name |
sodium;2,3-dihydroxypropyl [(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropyl] phosphate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 10 mg/mL
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.25 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.2970 mL | 6.4852 mL | 12.9703 mL | |
| 5 mM | 0.2594 mL | 1.2970 mL | 2.5941 mL | |
| 10 mM | 0.1297 mL | 0.6485 mL | 1.2970 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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