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|---|---|---|
| Other Sizes |
| Targets |
This compound does not have a specific biological target; it functions as an antimicrobial preservative. It is active against a wide range of food pathogens and spoilage organisms, with reports showing effects on bacterial cell membranes. It is used as a food antimicrobial in the sanitation of preserved foods and also in cosmetics as a preservative.
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| ln Vitro |
Commercial ergot supplements have been made from amino acids and their derivatives. They affect the release of anabolic hormones, the availability of fuel for activity, the ability to think clearly under pressure, and the prevention of muscular damage brought on by exertion. They are regarded as advantageous synergistic food ingredients [1].
This compound exhibits antimicrobial activity in vitro against a wide range of food pathogens and spoilage organisms. It shows effects on bacterial cell membranes, likely disrupting membrane integrity. It is used as a food-grade preservative due to its potent antimicrobial properties. |
| ln Vivo |
This compound is not used as a systemic therapeutic agent in vivo. It is a food preservative and cosmetic preservative. Its primary application is in food and cosmetic products for antimicrobial preservation, not for systemic administration in animals or humans.
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| Enzyme Assay |
In vitro antimicrobial assays are used to test the activity of this compound. A typical protocol involves testing the compound against a panel of food pathogens and spoilage organisms in culture media to determine its minimum inhibitory concentration (MIC). Its mechanism of action involves effects on bacterial cell membranes.
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| Cell Assay |
This compound is not used in cell-based assays as a therapeutic agent. Its role is as a food and cosmetic preservative. It should be stored under conditions to avoid air, moisture, and heat due to its hygroscopic and heat-sensitive nature.
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| Animal Protocol |
In vivo animal experiments are not typically performed with this compound as it is a food preservative, not a therapeutic agent. It may be used in food safety studies to evaluate its efficacy as a preservative in food products, but it is not administered as a drug.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties are not applicable as this is not a drug. It is a small molecule (MW not specified) with the formula C20H40N4O3·HCl. Its properties are relevant for its use as a food and cosmetic preservative. It has a density of 1.11 at 20°C.
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| Toxicity/Toxicokinetics |
The toxicity of this compound is relevant for its use as a food preservative. It is generally recognized as safe for its intended use in food and cosmetic products at approved concentrations. As a research chemical, it should be handled with standard laboratory precautions.
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| References | |
| Additional Infomation |
Ethyl Lauroyl Arginate Hydrochloride (LAE) is a cationic surfactant derived from natural sources (lauric acid and arginine) that is used as a highly potent food-grade preservative. It is active against a wide range of microorganisms and is used in food and cosmetic products. It is not a pharmaceutical and has no clinical trials or approved therapeutic status.
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| Molecular Formula |
C20H41CLN4O3
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|---|---|
| Molecular Weight |
421.02
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| Exact Mass |
420.286
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| CAS # |
60372-77-2
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| Related CAS # |
Ethyl Lauroyl Arginate Hydrochloride-d23
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| PubChem CID |
25229630
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| Appearance |
White to off-white solid powder
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| Melting Point |
57-61°C
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| LogP |
6.051
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
18
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| Heavy Atom Count |
28
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| Complexity |
423
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| Defined Atom Stereocenter Count |
1
|
| SMILES |
CCCCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)OCC.Cl
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| InChi Key |
CUBZMGWLVMQKNE-LMOVPXPDSA-N
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| InChi Code |
InChI=1S/C20H40N4O3.ClH/c1-3-5-6-7-8-9-10-11-12-15-18(25)24-17(19(26)27-4-2)14-13-16-23-20(21)22;/h17H,3-16H2,1-2H3,(H,24,25)(H4,21,22,23);1H/t17-;/m0./s1
|
| Chemical Name |
ethyl (2S)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoate;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~237.5 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.94 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.94 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (5.94 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3752 mL | 11.8759 mL | 23.7518 mL | |
| 5 mM | 0.4750 mL | 2.3752 mL | 4.7504 mL | |
| 10 mM | 0.2375 mL | 1.1876 mL | 2.3752 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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