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| Other Sizes |
| Targets |
This compound does not have a specific biological target; it functions as an antimicrobial preservative. It is active against a wide range of food pathogens and spoilage organisms, with reports showing effects on bacterial cell membranes. It is used as a food antimicrobial in the sanitation of preserved foods and also in cosmetics as a preservative.
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| ln Vitro |
Commercial ergot supplements have been made from amino acids and their derivatives. They affect the release of anabolic hormones, the availability of fuel for activity, the ability to think clearly under pressure, and the prevention of muscular damage brought on by exertion. They are regarded as advantageous synergistic food ingredients [1].
This compound exhibits antimicrobial activity in vitro against a wide range of food pathogens and spoilage organisms. It shows effects on bacterial cell membranes, likely disrupting membrane integrity. It is used as a food-grade preservative due to its potent antimicrobial properties. |
| ln Vivo |
This compound is not used as a systemic therapeutic agent in vivo. It is a food preservative and cosmetic preservative. Its primary application is in food and cosmetic products for antimicrobial preservation, not for systemic administration in animals or humans.
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| Enzyme Assay |
In vitro antimicrobial assays are used to test the activity of this compound. A typical protocol involves testing the compound against a panel of food pathogens and spoilage organisms in culture media to determine its minimum inhibitory concentration (MIC). Its mechanism of action involves effects on bacterial cell membranes.
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| Cell Assay |
This compound is not used in cell-based assays as a therapeutic agent. Its role is as a food and cosmetic preservative. It should be stored under conditions to avoid air, moisture, and heat due to its hygroscopic and heat-sensitive nature.
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| Animal Protocol |
In vivo animal experiments are not typically performed with this compound as it is a food preservative, not a therapeutic agent. It may be used in food safety studies to evaluate its efficacy as a preservative in food products, but it is not administered as a drug.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties are not applicable as this is not a drug. It is a small molecule (MW not specified) with the formula C20H40N4O3·HCl. Its properties are relevant for its use as a food and cosmetic preservative. It has a density of 1.11 at 20°C.
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| Toxicity/Toxicokinetics |
The toxicity of this compound is relevant for its use as a food preservative. It is generally recognized as safe for its intended use in food and cosmetic products at approved concentrations. As a research chemical, it should be handled with standard laboratory precautions.
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| References | |
| Additional Infomation |
Ethyl Lauroyl Arginate Hydrochloride (LAE) is a cationic surfactant derived from natural sources (lauric acid and arginine) that is used as a highly potent food-grade preservative. It is active against a wide range of microorganisms and is used in food and cosmetic products. It is not a pharmaceutical and has no clinical trials or approved therapeutic status.
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| Molecular Formula |
C20H41CLN4O3
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|---|---|
| Molecular Weight |
421.02
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| Exact Mass |
420.286
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| CAS # |
60372-77-2
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| PubChem CID |
25229630
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| Appearance |
White to off-white solid powder
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| Melting Point |
57-61°C
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| LogP |
6.051
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
18
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| Heavy Atom Count |
28
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| Complexity |
423
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CCCCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)OCC.Cl
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| InChi Key |
CUBZMGWLVMQKNE-LMOVPXPDSA-N
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| InChi Code |
InChI=1S/C20H40N4O3.ClH/c1-3-5-6-7-8-9-10-11-12-15-18(25)24-17(19(26)27-4-2)14-13-16-23-20(21)22;/h17H,3-16H2,1-2H3,(H,24,25)(H4,21,22,23);1H/t17-;/m0./s1
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| Chemical Name |
ethyl (2S)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoate;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3752 mL | 11.8759 mL | 23.7518 mL | |
| 5 mM | 0.4750 mL | 2.3752 mL | 4.7504 mL | |
| 10 mM | 0.2375 mL | 1.1876 mL | 2.3752 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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