| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 500mg |
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| Other Sizes |
| Targets |
This compound does not have a specific biological target; it functions as a specialized building block for peptide synthesis. As a pseudoproline dipeptide, it is used to overcome aggregation and enhance peptide quality in Fmoc SPPS for peptides containing the Phe-Ser dipeptide motif. The pseudoproline modification reversibly protects the Ser residue and disrupts β-sheet formation during synthesis. It is a crucial tool for studying biochemical pathways and provides insights into protein folding and interactions.
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|---|---|
| ln Vitro |
This compound is not a biological agent and does not exhibit direct in vitro biological activity in a pharmacological sense. Its value lies in its chemical utility as a specialized building block for improving peptide synthesis efficiency. It is a crucial tool for studying biochemical pathways and provides insights into protein folding and interactions. However, the compound itself is not tested for biological activity as a therapeutic agent.
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| ln Vivo |
This compound is not administered in vivo as a therapeutic agent. It is a research chemical utilized as a building block in peptide synthesis. The final deprotected peptide product, not this protected intermediate, would be the subject of in vivo pharmacological testing for therapeutic efficacy and safety. The pseudoproline dipeptide itself is never administered to animals as a test compound. It is used as a tool for overcoming aggregation in Fmoc SPPS.
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| Enzyme Assay |
Non-cellular enzyme/receptor binding assays are not applicable to Fmoc-Phe-Ser(psi(Me,Me)pro)-OH as it is not biologically active. Its use is in peptide synthesis. A typical protocol involves its use as a building block in Fmoc SPPS to introduce the Phe-Ser dipeptide motif while suppressing aggregation. The pseudoproline is stable during chain assembly and can be removed under TFA treatment during final cleavage. It is a crucial tool for studying biochemical pathways.
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| Cell Assay |
This compound is not used in cell-based assays as a therapeutic agent. Its role is as a research chemical and building block for peptide synthesis. It should be stored at -20°C. It is a dipeptide. Purity is typically high. The product is for research purposes only and is not intended for human or veterinary use. It is a crucial tool for studying biochemical pathways.
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| Animal Protocol |
In vivo animal experiments do not involve Fmoc-Phe-Ser(psi(Me,Me)pro)-OH as a test article. It is a chemical intermediate used in the synthesis of peptide-based drug candidates. If used to synthesize a therapeutic peptide, that final product would be subjected to animal testing. The pseudoproline dipeptide itself is not administered to animals as a therapeutic agent. It is used as a tool for overcoming aggregation in Fmoc SPPS.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties are not applicable to Fmoc-Phe-Ser(psi(Me,Me)pro)-OH as it is not a drug. It is a small molecule (MW 514.57 g/mol) with the formula C30H30N2O6. Its properties are relevant for chemical handling and storage rather than for systemic exposure studies. The pseudoproline modification is acid-labile and removed during final peptide cleavage.
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| Toxicity/Toxicokinetics |
The toxicity of Fmoc-Phe-Ser(psi(Me,Me)pro)-OH is not extensively documented, as it is a research chemical not intended for human or veterinary use. It should be handled with standard laboratory precautions, including the use of appropriate personal protective equipment and working in a well-ventilated area. The compound is a solid at room temperature and should be stored at -20°C. It is not intended for diagnostic, therapeutic, or other medical applications.
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| Additional Infomation |
This compound is a pseudoproline dipeptide consisting of an Fmoc-protected phenylalanine and a serine residue reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. It is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptides containing the Phe-Ser dipeptide motif. It is a crucial tool for studying biochemical pathways and provides insights into protein folding and interactions. It is not a pharmaceutical.
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| Molecular Formula |
C30H30N2O6
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|---|---|
| Molecular Weight |
514.57
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| Exact Mass |
514.21
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| CAS # |
878797-01-4
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| PubChem CID |
75535003
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| Appearance |
White to off-white solid powder
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| Density |
1.286±0.06 g/cm3(Predicted)
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| Boiling Point |
765.5±60.0 °C(Predicted)
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| LogP |
4.513
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
8
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| Heavy Atom Count |
38
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| Complexity |
849
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| Defined Atom Stereocenter Count |
2
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| SMILES |
C(C1C2=CC=CC=C2C2C=CC=CC1=2)OC(=O)N[C@@H](CC1C=CC=CC=1)C(N1C(C)(C)OC[C@H]1C(=O)O)=O
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| InChi Key |
PQJUKTSKOYOXMZ-UIOOFZCWSA-N
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| InChi Code |
InChI=1S/C30H30N2O6/c1-30(2)32(26(18-38-30)28(34)35)27(33)25(16-19-10-4-3-5-11-19)31-29(36)37-17-24-22-14-8-6-12-20(22)21-13-7-9-15-23(21)24/h3-15,24-26H,16-18H2,1-2H3,(H,31,36)(H,34,35)/t25-,26-/m0/s1
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| Chemical Name |
(4S)-3-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenylpropanoyl]-2,2-dimethyl-1,3-oxazolidine-4-carboxylic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 250 mg/mL (485.84 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.04 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.04 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9434 mL | 9.7169 mL | 19.4337 mL | |
| 5 mM | 0.3887 mL | 1.9434 mL | 3.8867 mL | |
| 10 mM | 0.1943 mL | 0.9717 mL | 1.9434 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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