| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
As a synthetic intermediate, D-α-Aminocyclohexylacetic acid has no specific biological target. Its role is to provide cyclohexylglycine residues in peptide chains. The cyclohexyl side chain introduces unique steric and conformational properties that can significantly alter peptide structure and biological activity. The compound does not interact with enzymes or receptors in pharmacological assays.
|
|---|---|
| ln Vitro |
Commercial ergot supplements have been made from amino acids and their derivatives. They affect the release of anabolic hormones, the availability of fuel for activity, the ability to think clearly under pressure, and the prevention of muscular damage brought on by exertion. They are regarded as advantageous synergistic food ingredients [1].
The in vitro activity of D-α-Aminocyclohexylacetic acid is measured by coupling efficiency in peptide synthesis. Typically, it reacts with resin-bound or free amines using standard coupling reagents. Coupling yields are typically high with this building block. No inherent biological activity is observed. |
| ln Vivo |
In vivo activity is not applicable.
|
| Enzyme Assay |
The in vitro enzyme/receptor binding (non-cellular) experimental workflow involves standard peptide synthesis procedures. A typical workflow: dissolve D-α-Aminocyclohexylacetic acid in appropriate solvent, activate the carboxylic acid (if needed), and couple with other amino acid derivatives using standard coupling reagents. Characterize by NMR and MS.
|
| Cell Assay |
In vitro cell-based experimental workflows are not performed on this compound.
|
| Animal Protocol |
In vivo animal experiments are not applicable.
|
| ADME/Pharmacokinetics |
The pharmacokinetic properties have not been characterized.
|
| Toxicity/Toxicokinetics |
The toxicological data are limited. Standard laboratory safety practices should be followed.
|
| References |
[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
|
| Additional Infomation |
D-α-Aminocyclohexylacetic acid is a glycine derivative featuring a cyclohexyl side chain. The compound is for research use only. It is not a drug and has no clinical trials or approvals.
|
| Molecular Formula |
C8H15NO2
|
|---|---|
| Molecular Weight |
157.21
|
| Exact Mass |
157.11
|
| CAS # |
14328-52-0
|
| PubChem CID |
736849
|
| Appearance |
White to off-white solid powder
|
| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
292.8±23.0 °C at 760 mmHg
|
| Melting Point |
256ºC
|
| Flash Point |
130.9±22.6 °C
|
| Vapour Pressure |
0.0±1.3 mmHg at 25°C
|
| Index of Refraction |
1.510
|
| LogP |
1.38
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
11
|
| Complexity |
141
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
C1CCC(CC1)[C@H](C(=O)O)N
|
| InChi Key |
WAMWSIDTKSNDCU-SSDOTTSWSA-N
|
| InChi Code |
InChI=1S/C8H15NO2/c9-7(8(10)11)6-4-2-1-3-5-6/h6-7H,1-5,9H2,(H,10,11)/t7-/m1/s1
|
| Chemical Name |
(2R)-2-amino-2-cyclohexylacetic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O: 8.33 mg/mL (52.99 mM)
H2O: 3.33 mg/mL (21.18 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 1 mg/mL (6.36 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.3609 mL | 31.8046 mL | 63.6092 mL | |
| 5 mM | 1.2722 mL | 6.3609 mL | 12.7218 mL | |
| 10 mM | 0.6361 mL | 3.1805 mL | 6.3609 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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