| Size | Price | |
|---|---|---|
| Other Sizes |
| ADME/Pharmacokinetics |
Metabolism / Metabolites
Trans-stilbene is converted to 4-hydroxy-trans-stilbene in rabbits and guinea pigs. /Excerpt from a table/ Studies on the cyclohydroxylation metabolites of trans-stilbene have shown that/…various polyhydroxybibenzyl derivatives are present in urine. Evidence suggests that bibenzyl compounds are formed by the reduction of stilbene compounds by microbial flora. In guinea pigs and rabbits, trans-stilbene is biotransformed into 4-hydroxystilbene, 4,4'-dihydroxystilbene, 3-hydroxy-4-methoxystilbene, and 3-methoxy-4-hydroxystilbene…However, in mice, only a small amount of trans-stilbene is converted to 4,4'-dihydroxystilbene. This paper presents a schematic diagram of the oxidative cleavage of stilbene ethylene bonds. For more complete data on the metabolism/metabolites of trans-1,2-diphenylethylene, please refer to the relevant literature. (6 cases in total), please visit the HSDB record page. |
|---|---|
| Toxicity/Toxicokinetics |
Non-Human Toxicity Values
Oral LD50 in mice: 920 mg/kg Intraperitoneal LD50 in mice: 6050 mg/kg |
| References | |
| Additional Infomation |
Trans-stilbene is a grayish-white crystal with a melting point of 122-124℃ and exhibits blue fluorescence. (NTP, 1992)
Stilbene is an olefin compound belonging to the benzene group. Trans-stilbene has been reported to exist in Alnus firma, Paeonia rockii, and other organisms with relevant data. It is an organic compound containing the 1,2-stilbene functional group. |
| Molecular Formula |
C14H12
|
|---|---|
| Molecular Weight |
180.25
|
| Exact Mass |
180.093
|
| CAS # |
103-30-0
|
| Related CAS # |
trans-Stilbene-13C2;153610-50-5;trans-Stilbene-d12;16341-52-9;trans-Stilbene-d10;20748-24-7;trans-Stilbene-d2;5284-44-6
|
| PubChem CID |
638088
|
| Appearance |
White to off-white solid powder
|
| Density |
1.0±0.1 g/cm3
|
| Boiling Point |
307.0±0.0 °C at 760 mmHg
|
| Melting Point |
123-125 °C(lit.)
|
| Flash Point |
128.5±9.7 °C
|
| Vapour Pressure |
0.0±0.3 mmHg at 25°C
|
| Index of Refraction |
1.659
|
| LogP |
4.83
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
0
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
14
|
| Complexity |
149
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1=CC=C(C=C1)/C=C/C2=CC=CC=C2
|
| InChi Key |
PJANXHGTPQOBST-VAWYXSNFSA-N
|
| InChi Code |
InChI=1S/C14H12/c1-3-7-13(8-4-1)11-12-14-9-5-2-6-10-14/h1-12H/b12-11+
|
| Chemical Name |
(E)-stilbene
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 50 mg/mL (277.39 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (13.87 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.5479 mL | 27.7393 mL | 55.4785 mL | |
| 5 mM | 1.1096 mL | 5.5479 mL | 11.0957 mL | |
| 10 mM | 0.5548 mL | 2.7739 mL | 5.5479 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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