| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Fenipentol does not target a specific protein or enzyme. As a choleretic agent, its mechanism of action involves stimulating bile and exocrine pancreatic secretion, although the precise molecular targets are not well characterized.
|
|---|---|
| ln Vitro |
The in vitro activity of Fenipentol is not extensively characterized. The compound's primary activity is its choleretic effect, stimulating bile and exocrine pancreatic secretion.
|
| ln Vivo |
The secretory volume of pancreatic juice and protein output in rats are increased by fenipentol (PHP) administered orally or intraduodenally at doses ranging from 50-200 mg/kg[2]. In rats, fenipentol (50–200 mg/kg for intraperitoneal and 5–10 mg/kg for intravenous) significantly enhances biliary secretion[2]. In dogs, fenipentol (25–200 mg/kg administered intraduodenally) promotes pancreatic secretion[2].
Fenipentol has demonstrated in vivo activity as an orally active choleretic agent. In canine models, fenipentol (25-200 mg/kg; intraduodenal administration) stimulates pancreatic secretion. |
| Enzyme Assay |
In vitro binding assays are not applicable for Fenipentol as its mechanism of action is not mediated through binding to a specific receptor or enzyme target.
|
| Cell Assay |
For in vitro cellular experiments, Fenipentol is not typically used in cell-based assays. The compound is primarily used in physiological studies of bile and pancreatic secretion.
|
| Animal Protocol |
For in vivo animal experiments, Fenipentol has been used in canine models to study its effects on pancreatic secretion. The compound is administered intraduodenally at doses of 25-200 mg/kg.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties of Fenipentol have not been extensively characterized. The compound has a molecular weight of 164.24-164.248 g/mol and is insoluble in water but soluble in alcohol and oils. It has a boiling point of 137°C at 2mm and a density of 0.96 g/cm³.
|
| Toxicity/Toxicokinetics |
Acute toxicity: oral-rat LD50 data is available. The compound is intended for research use only and not for human therapeutic applications. Standard laboratory safety precautions should be observed.
|
| References |
|
| Additional Infomation |
Fenipentol is a benzene compound. It has been reported that Fenipentol exists in Ligusticum chuanxiong, Cynanchum paniculatum, and other herbs, and relevant data exists.
Fenipentol (Pancoral) is a synthetic benzenoid compound and orally active choleretic agent that stimulates bile and exocrine pancreatic secretion. It has been used in research settings to study biliary and pancreatic function and has no clinical or therapeutic applications. |
| Molecular Formula |
C11H16O
|
|---|---|
| Molecular Weight |
164.24
|
| Exact Mass |
164.12
|
| CAS # |
583-03-9
|
| PubChem CID |
3338
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
0,96 g/cm3
|
| Boiling Point |
137°C 2mm
|
| Flash Point |
137°C/2mm
|
| Index of Refraction |
1.5080
|
| LogP |
2.91
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
12
|
| Complexity |
106
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CCCCC(C1=CC=CC=C1)O
|
| InChi Key |
OVGORFFCBUIFIA-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C11H16O/c1-2-3-9-11(12)10-7-5-4-6-8-10/h4-8,11-12H,2-3,9H2,1H3
|
| Chemical Name |
1-phenylpentan-1-ol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (608.87 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (15.22 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (15.22 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (15.22 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.0887 mL | 30.4433 mL | 60.8865 mL | |
| 5 mM | 1.2177 mL | 6.0887 mL | 12.1773 mL | |
| 10 mM | 0.6089 mL | 3.0443 mL | 6.0887 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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