| Size | Price | Stock | Qty |
|---|---|---|---|
| 250g |
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| 500g |
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| Other Sizes |
| Targets |
Ethyl cellulose does not have a defined biological target as a therapeutic agent. It is a pharmaceutical excipient and not a pharmacologically active compound. Its primary applications are in formulation science, where it serves as a coating agent, binder, and matrix former for controlled-release drug delivery systems. The compound is not intended to exert pharmacological effects. Its utility lies in its physical and chemical properties, such as its ability to form films and control the release of active pharmaceutical ingredients.
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| ln Vitro |
Ethyl cellulose is not characterized for in vitro pharmacological activity, as it is an excipient and not a drug substance. Its effects in biological systems are primarily related to its physical properties, such as its ability to form films and control drug release. It is not evaluated for direct biological activities such as enzyme inhibition or receptor modulation. In vitro studies may focus on its biocompatibility and its effects on drug dissolution and permeation in formulation development.
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| ln Vivo |
Ethyl cellulose is not used for in vivo pharmacological activity assessment as a drug compound. It is a pharmaceutical excipient and not a therapeutic agent. The compound is not intended to be administered for therapeutic purposes. Its safety and tolerability have been established through its use in approved pharmaceutical products. In vivo studies may evaluate its performance in drug delivery systems, such as its ability to control drug release and its biodegradation in the body.
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| Enzyme Assay |
Ethyl cellulose is not typically used in enzyme/receptor binding assays, as it is an excipient and not a pharmacologically active compound. Its properties are evaluated in the context of formulation development, such as its effects on drug release, film formation, and encapsulation efficiency. Standard pharmaceutical testing protocols, including dissolution testing and mechanical property analysis, are employed for its evaluation. Its interactions with drugs and other excipients are studied using analytical techniques.
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| Cell Assay |
Ethyl cellulose is not used in cell-based assays as a test compound, as it is an excipient and not a pharmacologically active agent. Its effects on cells are primarily related to its physical properties, such as its ability to form films and encapsulate drugs. It may be used in studies of drug delivery systems, where its biocompatibility and effects on cellular uptake of encapsulated compounds are evaluated. However, it is not evaluated for direct pharmacological effects.
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| Animal Protocol |
Ethyl cellulose is not used in animal studies as a pharmacological agent. It is a pharmaceutical excipient used in drug formulations. The compound may be used in in vivo studies to evaluate the performance of drug delivery systems, such as controlled-release formulations, where it serves as a matrix former or coating agent. Its safety has been established through its use in approved pharmaceutical products. It is not administered as a test compound for efficacy evaluations.
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| ADME/Pharmacokinetics |
Ethyl cellulose is a non-ionic cellulose ether with a molecular weight that varies depending on the degree of polymerization and ethoxyl substitution. It is a fine, free-flowing powder that is soluble in organic solvents but insoluble in water. The compound is used as a pharmaceutical excipient, including as a coating agent, binder, and matrix former for controlled-release formulations. It is typically stored as a powder at -20°C for up to 3 years or in solvent at -80°C for up to 1 year.
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| Toxicity/Toxicokinetics |
Ethyl cellulose is considered safe for use in pharmaceutical products when used in accordance with established guidelines. It is a non-toxic, biodegradable polymer derived from cellulose. As an excipient, it has been evaluated for safety in pharmaceutical formulations. Standard safety precautions should be observed when handling this compound, including the use of appropriate personal protective equipment. It is not intended for human therapeutic use as a drug substance.
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| References | |
| Additional Infomation |
Ethyl cellulose is a glycoside.
Ethyl cellulose (CAS#: 9004-57-3) is a non-ionic cellulose ether widely utilized in biochemical research and formulation science. It is a non-toxic, biodegradable polymer derived from cellulose. Ethyl cellulose can be used as a pharmaceutical excipient, such as a coating agent, flavoring agent, and tablet filler. It is also used to prepare nanoparticles for active compound delivery. The compound is not a drug and has not undergone clinical trials. It is an excipient and a research reagent. |
| Molecular Formula |
C23H24N6O4
|
|---|---|
| Molecular Weight |
448.47446
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| Exact Mass |
448.185
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| CAS # |
9004-57-3
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| PubChem CID |
24832091
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| Appearance |
WHITE NEEDLES FROM BENZENE
FREE-FLOWING, WHITE TO LIGHT TAN POWDER AVAILABLE COMMERCIALLY AS CLEAR FILM OR SHEET White, granular, thermoplastic solid |
| Density |
1.45
|
| Boiling Point |
654.2±55.0 °C at 760 mmHg
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| Melting Point |
151 °C
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| Flash Point |
349.5±31.5 °C
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| Vapour Pressure |
0.0±2.0 mmHg at 25°C
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| Index of Refraction |
1.14
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| LogP |
6.62
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
11
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| Rotatable Bond Count |
12
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| Heavy Atom Count |
31
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| Complexity |
496
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CCCCN(C1C=CC(/N=N/C2C(C#N)=CC([N+]([O-])=O)=CC=2C#N)=C(C)C=1)CCOC(=O)C
|
| InChi Key |
ZZSNKZQZMQGXPY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H38O11/c1-6-26-10-12-16(17(27-7-2)18(28-8-3)20(25-5)30-12)31-19-14(23)13(22)15(24-4)11(9-21)29-19/h11-23H,6-10H2,1-5H3
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| Chemical Name |
2-[4,5-diethoxy-2-(ethoxymethyl)-6-methoxyoxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
Ethanol : ~16.67 mg/mL
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2298 mL | 11.1490 mL | 22.2980 mL | |
| 5 mM | 0.4460 mL | 2.2298 mL | 4.4596 mL | |
| 10 mM | 0.2230 mL | 1.1149 mL | 2.2298 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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