| Size | Price | |
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| Other Sizes |
| Targets |
Choline bromide does not have a defined biological target as a therapeutic agent. Choline, the parent compound, is an essential nutrient that serves as a precursor for the neurotransmitter acetylcholine and for phospholipids in cell membranes. Choline bromide is used as a research chemical and a source of choline. It is not intended to exert pharmacological effects as a bromide salt.
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|---|---|
| ln Vitro |
Specific in vitro activity data for Choline bromide as a pharmacological agent are not documented in the literature. It is primarily used as a research chemical and a source of choline. The compound's effects in biological systems are related to the choline moiety, which is involved in acetylcholine synthesis and lipid metabolism. It is not characterized for direct biological activities such as enzyme inhibition or receptor modulation.
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| ln Vivo |
Choline bromide is not used for in vivo pharmacological activity assessment as a drug compound. It is a research chemical and a source of choline. Choline, the parent compound, is an essential nutrient that is used in studies of nutrition and metabolism. The bromide salt form is not intended to be administered for therapeutic purposes.
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| Enzyme Assay |
Choline bromide is not typically used in enzyme/receptor binding assays as a test compound. Its primary applications are as a research chemical and as a source of choline. When used in research, it may be employed in studies of choline metabolism or as a precursor for the synthesis of other choline derivatives.
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| Cell Assay |
Choline bromide is used in cell-based assays as a source of choline for studying choline metabolism and acetylcholine synthesis. Cells are treated with the compound to assess its effects on cellular choline levels, lipid metabolism, and neurotransmitter synthesis. Standard cell culture conditions (37°C, 5% CO₂) with appropriate media are employed.
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| Animal Protocol |
Choline bromide is used in animal studies as a source of choline in nutritional and metabolic studies. The compound may be administered via diet or injection to assess its effects on choline levels, liver function, and neurotransmitter synthesis. All procedures must comply with institutional animal care and use guidelines.
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| ADME/Pharmacokinetics |
Choline bromide has a molecular weight of 184.08 g/mol and a molecular formula of C₅H₁₄BrNO. It is a white crystalline solid. The compound is hygroscopic and should be stored under standard laboratory conditions, protected from moisture. It is soluble in water and organic solvents.
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| Toxicity/Toxicokinetics |
Choline bromide is intended for research use only and is not approved for human therapeutic applications. As a research chemical, comprehensive toxicological data are not extensively documented in the publicly accessible literature. Standard safety precautions should be observed when handling this compound, including the use of appropriate personal protective equipment. The compound should be handled in well-ventilated areas with proper waste disposal procedures.
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| Additional Infomation |
Choline bromide (CAS#: 1927-06-6) has a molecular formula of C₅H₁₄BrNO and a molecular weight of 184.08 g/mol. It is the bromide salt of choline, used as a research chemical and as a source of choline in biochemical studies. This compound is not a drug and has not undergone clinical trials.
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| Molecular Formula |
C5H14BRNO
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|---|---|
| Molecular Weight |
184.07
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| Exact Mass |
183.025
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| CAS # |
1927-06-6
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| Related CAS # |
Choline-1,1,2,2-d4 bromide;285979-69-3;Choline-d13 bromide;203645-64-1;Choline-d9 bromide;285979-71-7
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| PubChem CID |
74724
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| Appearance |
White to off-white solid powder
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| Melting Point |
298 °C
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
8
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| Complexity |
46.5
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[Br-].O([H])C([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
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| InChi Key |
JJCWKVUUIFLXNZ-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C5H14NO.BrH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1
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| Chemical Name |
2-hydroxyethyl(trimethyl)azanium;bromide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4327 mL | 27.1636 mL | 54.3272 mL | |
| 5 mM | 1.0865 mL | 5.4327 mL | 10.8654 mL | |
| 10 mM | 0.5433 mL | 2.7164 mL | 5.4327 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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