| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
(R)-2-Methylpiperazine does not have a defined biological target as a therapeutic agent. It is a chiral building block used in organic synthesis and drug discovery. The compound may be used in the synthesis of various bioactive molecules, including pharmaceuticals. Its biological activity would be determined by the final molecules into which it is incorporated. It is not characterized for direct pharmacological effects.
|
|---|---|
| ln Vitro |
Specific in vitro activity data for (R)-2-Methylpiperazine as a pharmacological agent are not documented in the literature. It is primarily used as a chiral building block. The compound's derivatives, particularly piperazine-containing pharmaceuticals, may exhibit various biological activities. However, the parent compound itself is not characterized for direct biological effects such as enzyme inhibition or receptor modulation.
|
| ln Vivo |
(R)-2-Methylpiperazine is not used for in vivo pharmacological activity assessment as a drug compound. Its primary application is as a chiral building block in organic synthesis. The compound is not intended to be administered to animals for pharmacological studies. Its derivatives, which are synthesized from this building block, may be evaluated in vivo depending on their therapeutic targets.
|
| Enzyme Assay |
As a chiral building block, (R)-2-Methylpiperazine is not typically used in enzyme/receptor binding assays. Its role is in the synthesis of compounds that may be evaluated in such assays. When used in research, it serves as a starting material for the preparation of various piperazine derivatives. Standard synthetic chemistry protocols, including reductive amination, acylation, and alkylation reactions, are employed for its use.
|
| Cell Assay |
(R)-2-Methylpiperazine is not used in cell-based assays as a test compound. Its primary application is as a chiral building block for the synthesis of more complex molecules. The compound's derivatives may be evaluated in cell-based assays for various biological activities, but the parent compound itself is not characterized for direct cellular effects.
|
| Animal Protocol |
(R)-2-Methylpiperazine is not used in animal studies as a pharmacological agent. Its primary application is as a chiral building block in organic synthesis. The compound is not intended to be administered to animals for efficacy or safety evaluations. Its derivatives may be evaluated in animal models depending on their therapeutic targets.
|
| ADME/Pharmacokinetics |
(R)-2-Methylpiperazine has a molecular weight of 100.16 g/mol and a molecular formula of C₅H₁₂N₂. It is a colorless to light yellow liquid or low-melting solid. The compound is soluble in water and organic solvents. It is typically stored under inert atmosphere, protected from moisture and carbon dioxide, as it is hygroscopic and may absorb CO₂ from the air.
|
| Toxicity/Toxicokinetics |
(R)-2-Methylpiperazine is intended for research use only and is not approved for human therapeutic applications. As a chiral building block, comprehensive toxicological data are not available in the publicly accessible literature. The compound may cause skin, eye, and respiratory tract irritation. Standard safety precautions should be observed when handling this compound, including the use of appropriate personal protective equipment. The compound should be handled in well-ventilated areas with proper waste disposal procedures.
|
| Additional Infomation |
See also: 2-methylpiperazine (note moved to).
(R)-2-Methylpiperazine (CAS#: 75336-86-6) has a molecular formula of C₅H₁₂N₂ and a molecular weight of 100.16 g/mol. It is a chiral piperazine derivative used as a building block in organic synthesis and medicinal chemistry for the preparation of pharmaceuticals. This compound is not a drug and has not undergone clinical trials. |
| Molecular Formula |
C5H12N2
|
|---|---|
| Molecular Weight |
100.16
|
| Exact Mass |
100.1
|
| CAS # |
75336-86-6
|
| PubChem CID |
7330434
|
| Appearance |
White to yellow solid powder
|
| Density |
0.8±0.1 g/cm3
|
| Boiling Point |
153.2±8.0 °C at 760 mmHg
|
| Melting Point |
86-93ºC
|
| Flash Point |
45.1±10.2 °C
|
| Vapour Pressure |
3.4±0.3 mmHg at 25°C
|
| Index of Refraction |
1.418
|
| LogP |
-0.68
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
7
|
| Complexity |
54
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
N1([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
|
| InChi Key |
JOMNTHCQHJPVAZ-RXMQYKEDSA-N
|
| InChi Code |
InChI=1S/C5H12N2/c1-5-4-6-2-3-7-5/h5-7H,2-4H2,1H3/t5-/m1/s1
|
| Chemical Name |
(2R)-2-methylpiperazine
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (998.40 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (24.96 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (24.96 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (24.96 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 9.9840 mL | 49.9201 mL | 99.8403 mL | |
| 5 mM | 1.9968 mL | 9.9840 mL | 19.9681 mL | |
| 10 mM | 0.9984 mL | 4.9920 mL | 9.9840 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
