| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mL |
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| Other Sizes |
| Targets |
Hexaethylene glycol monododecyl ether does not have a defined pharmacological target as it is a nonionic surfactant and biochemical reagent. The compound is commonly used as a surfactant and emulsifier. It plays a crucial role in formulating drug delivery systems and enhancing drug solubility. It is used in pharmaceutical research and drug development.
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|---|---|
| ln Vitro |
No specific in vitro pharmacological activity data are available for Hexaethylene glycol monododecyl ether as a drug candidate. In research settings, the compound is used as a surfactant, emulsifier, and in drug delivery system formulation. Its activity is assessed in terms of surfactant properties and formulation performance rather than biological activity.
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| ln Vivo |
No specific in vivo pharmacological activity data have been documented for Hexaethylene glycol monododecyl ether as a therapeutic agent. The compound is used as a surfactant and emulsifier in pharmaceutical research and drug development. It is not administered to animals for pharmacological evaluation. Its applications are limited to biochemical and pharmaceutical research.
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| Enzyme Assay |
For non-cellular assays, Hexaethylene glycol monododecyl ether is characterized by standard analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. The compound can be evaluated for its surfactant properties including critical micelle concentration and surface activity. Typical protocols involve preparing solutions of the compound in aqueous buffers. Purity: ≥97% to ≥98%.
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| Cell Assay |
For in vitro cell-based studies, Hexaethylene glycol monododecyl ether may be used in drug delivery formulation studies. The compound can be used to formulate liposomes or other delivery vehicles. Cells are cultured under standard conditions and treated with formulations containing the surfactant. Appropriate controls should be included in the experimental design.
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| Animal Protocol |
For in vivo animal studies, Hexaethylene glycol monododecyl ether can be formulated using standard injection vehicles. The compound is a solid at room temperature. Dosing solutions should be freshly prepared and administered according to specific protocols with appropriate control groups. The compound is used in pharmaceutical research and drug development.
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| ADME/Pharmacokinetics |
Hexaethylene glycol monododecyl ether has a molecular weight of 450.65 and molecular formula C24H50O7. It appears as a solid at room temperature. Purity: ≥97% to ≥98%. Storage: keep in a cool, dry place protected from light and moisture. The compound is stable under recommended storage conditions.
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| Toxicity/Toxicokinetics |
Toxicity Summary
The CIR panel concluded that the following alkyl polyethylene glycol ethers are safe under current usage methods and concentrations, and when formulated as non-irritating. This assessment also aims to cover potential future cosmetic ingredients containing alkyl polyethylene glycol ethers, which differ from those described herein only in the number of repeating glycol units… Lauryl ether-6… Safe for use in cosmetics under specific conditions. Hexaethylene glycol monododecyl ether is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD50 values and detailed toxicological profiles have not been extensively reported. |
| Additional Infomation |
See also: Laureth-6 (Notes moved to).
Hexaethylene glycol monododecyl ether (CAS 3055-96-7) is also known as C12E6. It is a nonionic surfactant widely utilized in biochemical and biophysical research. It plays a crucial role in formulating drug delivery systems and enhancing drug solubility. It is used in pharmaceutical research and drug development. |
| Molecular Formula |
C24H50O7
|
|---|---|
| Molecular Weight |
450.65
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| Exact Mass |
450.355
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| CAS # |
3055-96-7
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| PubChem CID |
18282
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| Appearance |
Colorless to off-white <27°C solid,>27°C liquid
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
521.0±45.0 °C at 760 mmHg
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| Melting Point |
27ºC
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| Flash Point |
268.9±28.7 °C
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| Vapour Pressure |
0.0±3.1 mmHg at 25°C
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| Index of Refraction |
1.456
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| LogP |
3.26
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
28
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| Heavy Atom Count |
31
|
| Complexity |
306
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCO
|
| InChi Key |
OJCFEGKCRWEVSN-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C24H50O7/c1-2-3-4-5-6-7-8-9-10-11-13-26-15-17-28-19-21-30-23-24-31-22-20-29-18-16-27-14-12-25/h25H,2-24H2,1H3
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| Chemical Name |
2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~200 mg/mL (~443.8 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (11.10 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 5 mg/mL (11.10 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2190 mL | 11.0951 mL | 22.1902 mL | |
| 5 mM | 0.4438 mL | 2.2190 mL | 4.4380 mL | |
| 10 mM | 0.2219 mL | 1.1095 mL | 2.2190 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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