| Size | Price | |
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| Other Sizes |
| Targets |
Polyoxyethylene Sorbitan Monostearate does not have a defined pharmacological target as it is a pharmaceutical excipient and surfactant. The compound is used to improve the stability, solubility, and processability of pharmaceutical preparations. It can also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs. Its primary function is formulation-based rather than therapeutic.
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|---|---|
| ln Vitro |
No specific in vitro pharmacological activity data are available for Polyoxyethylene Sorbitan Monostearate as a drug candidate. In research settings, the compound is evaluated for its emulsifying properties, solubilization capacity, and compatibility with active pharmaceutical ingredients. Its activity is assessed in terms of formulation performance, stability, and safety rather than direct biological activity.
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| ln Vivo |
No specific in vivo pharmacological activity data have been documented for Polyoxyethylene Sorbitan Monostearate as a therapeutic agent. The compound is used as a pharmaceutical excipient and is generally considered pharmacologically inert. It is not administered for therapeutic purposes but as a formulation component in drug products.
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| Enzyme Assay |
For non-cellular assays, Polyoxyethylene Sorbitan Monostearate is characterized by standard analytical techniques including HPLC and physical property testing to confirm identity and quality. The compound can be evaluated for its emulsifying properties, surface activity, and saponification value (43.0 to 55.0). Freezing point: 21.0 to 25.0°C. Purity is typically ≥98%.
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| Cell Assay |
For in vitro cell-based studies, Polyoxyethylene Sorbitan Monostearate may be used as a component of cell culture media or as a solubilizing agent for hydrophobic test compounds. The compound is typically dissolved in aqueous buffers or cell culture medium at appropriate concentrations. Cells are cultured under standard conditions and exposed to formulations containing the surfactant to assess biocompatibility.
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| Animal Protocol |
For in vivo animal studies, Polyoxyethylene Sorbitan Monostearate may be used as an excipient in drug formulations for administration via various routes. The compound is typically formulated with active pharmaceutical ingredients to improve solubility and bioavailability. Dosing solutions should be prepared according to the specific formulation protocol. Standard animal welfare guidelines should be followed.
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| ADME/Pharmacokinetics |
Polyoxyethylene Sorbitan Monostearate has a molecular weight of 434.56 and formula C₂₂H₄₂O₈. It appears as a colorless to light yellow viscous liquid with a density of 1.081 and boiling point of 583.8±50.0°C. Flash point: 190.4±23.6°C. LogP: 8.09. The compound has 3 hydrogen bond donors, 8 acceptors, and 20 rotatable bonds. Storage: room temperature in a cool and dark place (<15°C).
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| Toxicity/Toxicokinetics |
Toxicity Summary
The CIR panel concluded that the following polysorbates are safe for use in cosmetics when formulated as non-irritating agents. This conclusion supersedes the findings of the 1984, 2000, and 2001 CIR safety assessments… Polysorbate 60… Under certain conditions, it is safe for use in cosmetics. Polyoxyethylene Sorbitan Monostearate is for research and pharmaceutical use only and not for human consumption without regulatory approval. Standard laboratory safety practices should be followed when handling this compound. Appropriate personal protective equipment including gloves and safety glasses should be worn. The compound is generally regarded as safe for use as a pharmaceutical excipient at appropriate concentrations. |
| References |
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| Additional Infomation |
1,4-Dehydrated-6-O-dodecanoyl-2,3-bis-O-(2-hydroxyethyl)-D-glucanol is a fatty acid ester.
Polyoxyethylene Sorbitan Monostearate (CAS 9005-67-8) is also known as Tween 61, PEG-4 sorbitan stearate, and polysorbate 61. It has a Unique Ingredient Identifier of 90SOR12GHG. The compound is used as a surfactant, emulsifier, solubilizer, and wetting agent in pharmaceutical formulations. No therapeutic claims exist for the compound itself. |
| Molecular Formula |
C22H42O8
|
|---|---|
| Molecular Weight |
434.5641
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| Exact Mass |
434.287
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| CAS # |
9005-67-8
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| Related CAS # |
9005-67-8
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| PubChem CID |
22833389
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| Appearance |
Colorless to light yellow viscous liquid
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| Density |
1.081
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| Boiling Point |
583.8±50.0 °C at 760 mmHg
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| Flash Point |
190.4±23.6 °C
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| Vapour Pressure |
0.0±3.7 mmHg at 25°C
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| Index of Refraction |
1.499
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| LogP |
8.09
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| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
20
|
| Heavy Atom Count |
30
|
| Complexity |
420
|
| Defined Atom Stereocenter Count |
4
|
| SMILES |
O1C([H])([H])[C@@]([H])([C@]([H])([C@@]1([H])[C@@]([H])(C([H])([H])OC(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O)O[H])OC([H])([H])C([H])([H])O[H])OC([H])([H])C([H])([H])O[H]
|
| InChi Key |
CRBBOOXGHMTWOC-NPDDRXJXSA-N
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| InChi Code |
InChI=1S/C22H42O8/c1-2-3-4-5-6-7-8-9-10-11-20(26)29-16-18(25)21-22(28-15-13-24)19(17-30-21)27-14-12-23/h18-19,21-25H,2-17H2,1H3/t18-,19+,21-,22-/m1/s1
|
| Chemical Name |
[(2R)-2-[(2R,3R,4S)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-hydroxyethyl] dodecanoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3012 mL | 11.5059 mL | 23.0118 mL | |
| 5 mM | 0.4602 mL | 2.3012 mL | 4.6024 mL | |
| 10 mM | 0.2301 mL | 1.1506 mL | 2.3012 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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