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| Targets |
4-(2-Methyl-4-thiazolyl)phenol does not have a defined pharmacological target as it is a chemiluminescence enhancer and biochemical reagent. The compound is a potent peroxidase chemiluminescence enhancer for HRP. Its primary function is to enhance the signal in chemiluminescent detection systems. The compound is used in biochemical research and diagnostic applications.
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| ln Vitro |
In vitro activity of 4-(2-Methyl-4-thiazolyl)phenol is assessed in chemiluminescence assays. The compound serves as a potent peroxidase chemiluminescence enhancer for horseradish peroxidase (HRP), enabling sensitive detection in immunoassays and other biochemical applications. Its activity is measured by the enhancement of chemiluminescent signal in HRP-based detection systems.
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| ln Vivo |
No specific in vivo pharmacological activity data have been documented for 4-(2-Methyl-4-thiazolyl)phenol as a therapeutic agent. The compound is used as a chemiluminescence enhancer and biochemical reagent. It is not administered to animals for pharmacological evaluation. Its applications are limited to in vitro biochemical and diagnostic research.
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| Enzyme Assay |
For non-cellular assays, 4-(2-Methyl-4-thiazolyl)phenol is characterized by standard analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. Purity is ≥98% by HPLC. The compound has a molecular weight of 191.25 and formula C₁₀H₉NOS. Storage: room temperature in a cool and dark place (<15°C). Typical protocols involve using the compound as a chemiluminescence enhancer in HRP-based assays.
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| Cell Assay |
For in vitro cell-based studies, 4-(2-Methyl-4-thiazolyl)phenol is not typically used as a direct test compound. It is used as a chemiluminescence enhancer in biochemical and diagnostic assays. If handled in a biological laboratory context, standard safety precautions should be taken. The compound should be stored in a cool, dry place protected from light and moisture.
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| Animal Protocol |
For in vivo animal studies, 4-(2-Methyl-4-thiazolyl)phenol is not typically administered as a test compound. It is used as a chemiluminescence enhancer and biochemical reagent in in vitro assays. If used in animal studies for specific research purposes, it would be administered via appropriate routes with suitable formulations.
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| ADME/Pharmacokinetics |
4-(2-Methyl-4-thiazolyl)phenol has a molecular weight of 191.25 and formula C₁₀H₉NOS. Purity: ≥98% by HPLC. Storage: room temperature in a cool and dark place (<15°C). The compound is a solid at room temperature. Solubility: soluble in common organic solvents.
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| Toxicity/Toxicokinetics |
4-(2-Methyl-4-thiazolyl)phenol is for research use only and not for human consumption. Standard laboratory safety practices should be followed when handling this chemical. Appropriate personal protective equipment including gloves and safety glasses should be worn. Specific LD₅₀ values and detailed toxicological profiles have not been extensively reported.
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| Additional Infomation |
4-(2-Methyl-4-thiazolyl)phenol (CAS 30686-73-8) is also known as 4-(2-methyl-1,3-thiazol-4-yl)phenol. It is a potent peroxidase chemiluminescence enhancer for HRP and is used for biochemical research. No clinical trials or therapeutic approvals exist.
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| Molecular Formula |
C10H9NOS
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| Molecular Weight |
191.25
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| Exact Mass |
191.04
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| CAS # |
30686-73-8
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| PubChem CID |
591743
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| Appearance |
White to off-white solid powder
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| Density |
1.257g/cm3
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| Boiling Point |
344.3ºC at 760 mmHg
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| Flash Point |
162ºC
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| Index of Refraction |
1.628
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| LogP |
2.824
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
13
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| Complexity |
168
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC1=NC(=CS1)C2=CC=C(C=C2)O
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| InChi Key |
HOAYTTLLVORNLA-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C10H9NOS/c1-7-11-10(6-13-7)8-2-4-9(12)5-3-8/h2-6,12H,1H3
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| Chemical Name |
4-(2-methyl-1,3-thiazol-4-yl)phenol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 50 mg/mL (261.44 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1 mg/mL (5.23 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1 mg/mL (5.23 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 1 mg/mL (5.23 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.2288 mL | 26.1438 mL | 52.2876 mL | |
| 5 mM | 1.0458 mL | 5.2288 mL | 10.4575 mL | |
| 10 mM | 0.5229 mL | 2.6144 mL | 5.2288 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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