Metabolism / Metabolites
Chromic can be absorbed orally, through inhalation, or through skin contact, and is distributed to almost all tissues, with the highest concentrations in the kidneys and liver. Bones are also a major storage site, potentially leading to long-term retention. Hexavalent Chromic is structurally similar to sulfates and chromates and can enter cells via the sulfate transport mechanism. Intracellularly, hexavalent Chromic is first reduced to pentavalent Chromic, and then further reduced to trivalent Chromic by various substances, including ascorbic acid, glutathione, and nicotinamide adenine dinucleotide. Almost all Chromic is excreted in urine. (A12, L16)

Toxicity Summary
Identification and Uses: Chromic acetate (III) is a blue-violet crystalline powder. It is not currently registered as a pesticide in the United States, but approved pesticide uses may change periodically, so it is essential to consult federal, state, and local authorities for its currently approved uses. It is used in dyeing; tanning; hardening photographic emulsions; as an oxidizing catalyst; improving the light stability and dye affinity of textiles and polymers; and as a catalyst for olefin polymerization. Human Exposure and Toxicity: No data are available. Animal Studies: No increased incidence of tumors was observed in oral administration to mice and rats, and in intrapleural and intramuscular injections of Chromic acetate (III) to rats. The Salmonella Typhimurium TA102 strain is particularly suitable for detecting oxidative mutagens, and among nine Salmonella Typhimurium strains, it is the most sensitive to the mutagenicity of hexavalent Chromic compounds. The sensitivity ranking of the strains is as follows: TA102, TA100, TA97, TA92, TA1978, TA98, TA1538, and TA1537, with TA1535 being the only insensitive strain. Trivalent Chromic compounds (Chromic acetate, Chromic nitrate, and potassium Chromic sulfate) showed no activity against any of the strains. Trivalent Chromic can also form complexes with peptides, proteins, and DNA, leading to DNA-protein cross-links, DNA strand breaks, DNA-DNA interstrand cross-links, Chromic-DNA adducts, chromosomal aberrations, and alterations in cell signaling pathways. Studies have shown that Chromic can induce carcinogenesis by increasing peroxide levels through overstimulation of cellular regulatory pathways and activation of certain mitogen-activated protein kinases. It can also inhibit histone modification by cross-linking the histone deacetylase 1-DNA methyltransferase 1 complex to the CYP1A1 promoter chromatin, thereby causing transcriptional repression. Chromic may enhance its autotoxicity by modifying metal-regulated transcription factor 1, leading to inhibition of zinc-induced metallothionein transcription. (A12, L16, A34, A35, A36)

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Toxicity Data
LD50: 2365 mg/kg/day (oral, rat) (L16)

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Non-human Toxicity Values
LD50: 2365 mg/kg/day of Chromic acetate (III) in male Cartworth-Wistar rats via oral administration.

[1]. Rheological and transport properties of sulfonated polyacrylamide hydrogels for water shutoff in porous media. Polym. Adv. Technol. 2014, 25 396-405.

Chromic acetate is a grayish-green to blue-green powder. Its main hazard lies in its environmental threat. Immediate measures should be taken to limit its spread into the environment. It is used in tanning and textile dyeing.
Trivalent Chromic acetate is a compound of Chromic. Chromic is a chemical element with the symbol Cr and atomic number 24. It exists naturally in rocks, animals, plants, and soil, and is usually mined as chromite. Hexavalent Chromic (Cr(VI)) is the most toxic because it is more readily absorbed into cells and has a higher redox potential. However, trivalent Chromic (Cr(III)) is essential for human sugar and lipid metabolism. (L17)
See also: Acetic acid, Chromic salts, basics (note moved to).

C6H9CRO6

229.13

228.98

1066-30-4

14012

Light green to green solid powder

1.705

212 °F at 760 mmHg

>400 °C

0.041

0

6

0

13

25.5

0

WYYQVWLEPYFFLP-UHFFFAOYSA-K

InChI=1S/3C2H4O2.Cr/c3*1-2(3)4;/h3*1H3,(H,3,4);/q;;;+3/p-3

chromium(3+);triacetate

2934.99.9001

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

DMSO: 14.29 mg/mL (62.37 mM)

Solubility in Formulation 1: ≥ 1.43 mg/mL (6.24 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 14.3 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.

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Solubility in Formulation 2: ≥ 1.43 mg/mL (6.24 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 14.3 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.

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 (Please use freshly prepared in vivo formulations for optimal results.)