| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 250mg |
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| Other Sizes |
| Targets |
Dodecane-d26 does not have a biological target as it is an analytical standard. Its non-deuterated form, n-dodecane, is a saturated hydrocarbon with no pharmacological activity. Alkanes are biologically inert and do not interact with specific receptors or enzymes. The compound is used exclusively as an analytical standard for the identification and quantification of hydrocarbons in complex mixtures.
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|---|---|
| ln Vitro |
Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
The labeled compound does not possess in vitro biological activity. n-Dodecane is a non-polar hydrocarbon that is not soluble in aqueous media and does not interact with cellular systems. Its utility is demonstrated in analytical applications, where it serves as a retention time marker and internal standard for GC-MS analysis of hydrocarbon mixtures. |
| ln Vivo |
Dodecane-d26 does not have in vivo biological activity and is not used for therapeutic purposes. n-Dodecane is a hydrocarbon that is not metabolized or utilized by mammalian systems. The compound is used as an analytical standard for environmental monitoring and petrochemical analysis, not for biological or pharmacological studies.
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| Enzyme Assay |
In vitro assays for dodecane-d26 focus on its use as an analytical standard. A standard protocol involves preparing a solution of the compound in an appropriate solvent (e.g., hexane) at a known concentration. The solution is injected into a GC-MS system equipped with a non-polar capillary column. The compound elutes at a characteristic retention time and produces a distinct mass spectrum with a molecular ion at m/z corresponding to the fully deuterated molecule.
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| Cell Assay |
Cell-based experiments are not performed with dodecane-d26, as it is a hydrocarbon standard with no biological activity. The compound is used exclusively in analytical chemistry applications.
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| Animal Protocol |
In vivo animal studies are not conducted with dodecane-d26, as it is an analytical standard. The compound is not used in pharmacological or toxicological studies.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of dodecane-d26 are not characterized, as it is not a drug substance. n-Dodecane is a highly lipophilic hydrocarbon that is not absorbed significantly after oral or dermal exposure. The compound is not intended for human exposure.
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| Toxicity/Toxicokinetics |
Dodecane-d26 is not a therapeutic agent and has not been evaluated for toxicity in humans. n-Dodecane is a saturated hydrocarbon with low toxicity. Standard laboratory safety precautions should be followed when handling this compound, including the use of gloves and safety glasses.
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| References | |
| Additional Infomation |
Dodecane-d26 is a stable isotope-labeled internal standard used for the quantification of hydrocarbons in environmental, petrochemical, and biological samples. It is also known as n-dodecane-d26. The compound is used in analytical method development, quality control, and environmental monitoring studies.
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| Molecular Formula |
C12D26
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|---|---|
| Molecular Weight |
196.50
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| Exact Mass |
196.366
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| CAS # |
16416-30-1
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| PubChem CID |
16213433
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.8±0.1 g/cm3
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| Boiling Point |
216.1±3.0 °C at 760 mmHg
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| Melting Point |
-9.6ºC(lit.)
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| Flash Point |
71.1±0.0 °C
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| Vapour Pressure |
0.2±0.2 mmHg at 25°C
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| Index of Refraction |
1.422
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| LogP |
7.13
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
0
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| Rotatable Bond Count |
9
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| Heavy Atom Count |
12
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| Complexity |
56.4
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[2H]C(C(C(C(C(C(C(C(C(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H]
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| InChi Key |
SNRUBQQJIBEYMU-DWXHPOBZSA-N
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| InChi Code |
InChI=1S/C12H26/c1-3-5-7-9-11-12-10-8-6-4-2/h3-12H2,1-2H3/i1D3,2D3,3D2,4D2,5D2,6D2,7D2,8D2,9D2,10D2,11D2,12D2
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| Chemical Name |
1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-hexacosadeuteriododecane
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (508.91 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.72 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (12.72 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (12.72 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.0891 mL | 25.4453 mL | 50.8906 mL | |
| 5 mM | 1.0178 mL | 5.0891 mL | 10.1781 mL | |
| 10 mM | 0.5089 mL | 2.5445 mL | 5.0891 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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