| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| Other Sizes |
| Targets |
Tributyl phosphate-d27 does not have a biological target as it is an analytical standard. Its non-deuterated form, tributyl phosphate, is an organophosphorus compound used as a solvent, plasticizer, and extractant in various industrial applications, including nuclear fuel reprocessing. It is not a pharmacologically active compound. The labeled compound is used as an internal standard for the quantification of TBP in environmental and analytical samples.
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|---|---|
| ln Vitro |
Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
The labeled compound does not possess in vitro biological activity. Tributyl phosphate is an industrial chemical that is not pharmacologically active. The labeled compound is used as an analytical standard for the quantification of TBP, not for evaluating its own biological activity. |
| ln Vivo |
Tributyl phosphate-d27 does not have in vivo biological activity and is not used for therapeutic purposes. Tributyl phosphate is used as a solvent and extractant in industrial applications. The labeled compound is used as an internal standard for the quantification of TBP in environmental and analytical samples.
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| Enzyme Assay |
In vitro assays for tributyl phosphate-d27 focus on its use as an analytical standard. A standard protocol involves preparing a solution of the compound in an appropriate solvent (e.g., hexane) and using it as an internal standard for GC-MS or LC-MS analysis of tributyl phosphate in environmental samples (e.g., water, soil) or nuclear waste samples. The compound is added to samples before extraction and analysis. Quantification is performed by monitoring specific mass transitions for the labeled and unlabeled compounds.
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| Cell Assay |
Cell-based experiments are not performed with tributyl phosphate-d27, as it is an analytical standard. The compound is used exclusively in analytical chemistry applications.
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| Animal Protocol |
In vivo animal studies are not conducted with tributyl phosphate-d27. When used in environmental monitoring, the labeled compound serves as an internal standard for the quantification of TBP in samples.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of tributyl phosphate-d27 are not characterized, as it is not a drug substance. Tributyl phosphate is absorbed after exposure and metabolized. The labeled compound is used as an internal standard for analytical purposes.
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| Toxicity/Toxicokinetics |
Tributyl phosphate-d27 may cause skin and eye irritation. Standard laboratory safety precautions should be followed when handling this compound, including the use of gloves and safety glasses.
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| References | |
| Additional Infomation |
Tributyl phosphate-d27 is a stable isotope-labeled internal standard used for the quantification of tributyl phosphate in environmental, nuclear, and analytical samples. It is also known as TBP-d27. The compound is used in analytical method development, quality control, and environmental monitoring.
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| Molecular Formula |
C12D27O4P
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|---|---|
| Molecular Weight |
293.48
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| Exact Mass |
275.221
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| CAS # |
61196-26-7
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| PubChem CID |
124202817
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| Appearance |
Colorless to light yellow liquid
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| LogP |
4.544
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
12
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| Heavy Atom Count |
17
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| Complexity |
175
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCCOP(OC(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])(=O)OCCCC
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| InChi Key |
STCOOQWBFONSKY-DGRGSPICSA-N
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| InChi Code |
InChI=1S/C12H27O4P/c1-4-7-10-14-17(13,15-11-8-5-2)16-12-9-6-3/h4-12H2,1-3H3/i1D3,2D3,3D3,4D2,5D2,6D2,7D2,8D2,9D2,10D2,11D2,12D2
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| Chemical Name |
tris(1,1,2,2,3,3,4,4,4-nonadeuteriobutyl) phosphate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ≥ 100 mg/mL (~340.7 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.52 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.52 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (8.52 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4074 mL | 17.0369 mL | 34.0739 mL | |
| 5 mM | 0.6815 mL | 3.4074 mL | 6.8148 mL | |
| 10 mM | 0.3407 mL | 1.7037 mL | 3.4074 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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