| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| Other Sizes |
| Targets |
Momordin IIc targets alpha-glucosidase, an enzyme that breaks down carbohydrates into glucose, with weak inhibitory activity (IC₅₀ > 50 µM). It also targets human renin, an enzyme involved in blood pressure regulation, with an IC₅₀ of 0.0468 mM. The compound shows 1.2-fold greater potency than glycyrrhizin (IC₅₀ 0.0571 mM) and 1.7-fold greater potency than chikusetsusaponin IV (IC₅₀ 0.0774 mM).
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|---|---|
| ln Vitro |
In vitro, momordin IIc demonstrates weak inhibitory activity against alpha-glucosidase (IC₅₀ > 50 µM). It also demonstrates human renin inhibitory activity with an IC₅₀ of 0.0468 mM. The compound is a natural triterpene isolated from Kochiae Fructus. It is also known as Quinoside D and is a triterpenoid glycoside isolated from Bougainvillea glabra.
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| ln Vivo |
Momordin IIc is not a pharmacologically approved drug. It is a natural product used in research for its enzyme inhibitory activities. The compound has not been evaluated in clinical trials and is not approved for therapeutic use. It is a research compound used to study alpha-glucosidase and renin inhibition.
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| Enzyme Assay |
In vitro assays for momordin IIc typically involve enzyme inhibition studies. A standard protocol for alpha-glucosidase inhibition involves incubating the enzyme with a chromogenic substrate (e.g., p-nitrophenyl-α-D-glucopyranoside) in the presence of varying concentrations of momordin IIc (typically 1-100 µM). The release of p-nitrophenol is measured spectrophotometrically at 405 nm. IC₅₀ values are calculated from dose-response curves.
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| Cell Assay |
In vitro cell culture experiments with momordin IIc are not standard, as it is primarily an enzyme inhibitor research compound. When studying its effects, cells are treated with the compound at concentrations ranging from 1-100 µM, and enzyme activity or cell viability is measured. The compound is used to study alpha-glucosidase and renin inhibition.
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| Animal Protocol |
In vivo animal studies with momordin IIc are not well documented, as it is primarily a research compound. If conducted, typical protocols for antihyperglycemic studies would involve administering the compound to diabetic animal models and measuring blood glucose levels. However, such studies are not standard for this compound.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of momordin IIc are not characterized, as it is not a drug substance. Based on its physicochemical properties (molecular weight 927.08), the compound would be expected to have limited oral bioavailability. The compound is not intended for human exposure.
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| Toxicity/Toxicokinetics |
Momordin IIc may cause skin and eye irritation. Standard laboratory safety precautions should be followed when handling this compound, including the use of gloves, safety glasses, and working in a fume hood. The compound should be stored in a cool, dry place away from light and moisture.
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| References | |
| Additional Infomation |
Matrine IIc has been reported to have been found in Malabar spinach, sugar beets, and other organisms with available data.
Momordin IIc (Quinoside D) is a triterpenoid glycoside isolated from Bougainvillea glabra. It demonstrates weak inhibitory activity against alpha-glucosidase (IC₅₀ > 50 µM) and human renin inhibitory activity (IC₅₀ 0.0468 mM). It has not undergone clinical trials and is not approved as a pharmaceutical. |
| Molecular Formula |
C47H74O18
|
|---|---|
| Molecular Weight |
927.07967710495
|
| Exact Mass |
926.487
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| CAS # |
96990-19-1
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| PubChem CID |
14162557
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| Appearance |
White to off-white solid
|
| LogP |
2.8
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| Hydrogen Bond Donor Count |
10
|
| Hydrogen Bond Acceptor Count |
18
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| Rotatable Bond Count |
9
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| Heavy Atom Count |
65
|
| Complexity |
1830
|
| Defined Atom Stereocenter Count |
22
|
| SMILES |
C[C@]12CC[C@@H](C([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)(C)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)O
|
| InChi Key |
BAJBCZHVQXVBMJ-PQLKQRIHSA-N
|
| InChi Code |
InChI=1S/C47H74O18/c1-42(2)14-16-47(41(59)65-39-32(54)30(52)29(51)24(19-48)61-39)17-15-45(6)21(22(47)18-42)8-9-26-44(5)12-11-27(43(3,4)25(44)10-13-46(26,45)7)62-40-34(56)35(33(55)36(64-40)37(57)58)63-38-31(53)28(50)23(49)20-60-38/h8,22-36,38-40,48-56H,9-20H2,1-7H3,(H,57,58)/t22-,23-,24-,25?,26?,27?,28+,29-,30+,31-,32-,33+,34-,35+,36+,38+,39+,40-,44+,45-,46-,47+/m1/s1
|
| Chemical Name |
(2S,3S,4S,5R,6R)-6-[[(6aR,6bS,8aS,12aR,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,5-dihydroxy-4-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxane-2-carboxylic acid
|
| Synonyms |
Quinoside D; Momordin IIc
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (107.87 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (2.70 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (2.70 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.0787 mL | 5.3933 mL | 10.7866 mL | |
| 5 mM | 0.2157 mL | 1.0787 mL | 2.1573 mL | |
| 10 mM | 0.1079 mL | 0.5393 mL | 1.0787 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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