| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Methyl laurate activates nuclear receptors such as retinoid X receptor alpha (RXRα), estrogen receptor alpha (ERα), androgen receptor (AR), thyroid hormone receptor beta (THRβ), and peroxisome proliferator-activated receptors delta and gamma (PPARδ/γ). It also inhibits signaling pathways associated with the farnesoid X receptor (FXR), vitamin D receptor (VDR), glucocorticoid receptor (GR), and RXRα. It modulates NF-κB, p53, and antioxidant response element (ARE) pathways.
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|---|---|
| ln Vitro |
In vitro, methyl laurate exhibits a broad spectrum of bioactivities. It shows significant antimicrobial properties against various pathogens. It has been shown to be an effective catalyst for biodiesel production. Methyl laurate modulates the activity of nuclear receptors and transcription factors. It also has effects on immune function.
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| ln Vivo |
Methyl laurate is not a pharmacologically approved drug. It is a fatty acid ester used as a flavoring agent and in research. It has not been evaluated in clinical trials for therapeutic use.
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| Enzyme Assay |
In vitro assays for methyl laurate typically involve cell-based reporter gene assays to study nuclear receptor activation. A standard protocol involves transfecting cells with a luciferase reporter construct containing response elements for the receptor of interest. Cells are treated with varying concentrations of methyl laurate (typically 1-100 µM) for 24 hours, and luciferase activity is measured. Cell viability is assessed using MTT assays.
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| Cell Assay |
In vitro cell culture experiments with methyl laurate are conducted to study its effects on nuclear receptor signaling and antimicrobial activity. Cells are cultured in appropriate media and treated with the compound at concentrations ranging from 1-100 µM for 24-72 hours. Reporter gene activity, cell viability, and antimicrobial effects are measured.
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| Animal Protocol |
In vivo animal studies with methyl laurate are not well documented. It is used primarily as a research compound and flavoring agent.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of methyl laurate are not characterized, as it is not a drug substance. Based on its physicochemical properties (molecular weight 214.34, soluble in ethanol at 30 mg/mL), the compound would be expected to have moderate bioavailability. However, it is not intended for human exposure.
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| Toxicity/Toxicokinetics |
Interactions
Linear saturated fatty acid methyl esters and lectins exhibit coagulation effects on mouse lymphocytes. The degree of coagulation strongly depends on the length of the acyl group, with methyl tetradecanoate showing the strongest coagulation. Analogs containing 10, 12, or 16 acyl carbon atoms have weaker effects, while analogs with fewer than 10 or more than 16 acyl carbon atoms are inactive. /Methyl ester/ Methyl laurate has low toxicity but is a hazard for the environment, with acute aquatic toxicity values between 0.01 and 1.0 mg/L for invertebrates and algae. Standard laboratory safety precautions should be followed when handling this compound, including the use of gloves and safety glasses. |
| References | |
| Additional Infomation |
Methyl lauryl acid is a fatty acid methyl ester of lauric acid and is a metabolite. It is both a fatty acid methyl ester and a lauryl ester. Methyl lauryl acid has been reported to be found in mandrake (Mandragora autumnalis), citrus (Citrus iyo), and other organisms with relevant data. Methyl lauryl acid is found in alcoholic beverages. It is also found in Concord grapes (Vitis labrusca), melons, pineapples, baked blackberries, red peppers (Capsicum frutescens), and other fruits. Furthermore, it is found in cheese, hop oil, white wine, spirits, and other foods. Methyl lauryl acid is a flavoring agent. Methyl lauryl acid belongs to the fatty acid ester class. These are carboxylic acid ester derivatives of fatty acids.
Therapeutic Uses Experimental Uses: Administering 5 mg of methyl lauryl acid to mice injected intraperitoneally with 106 Ehrlich ascites tumor cells daily for 5 days prolonged their survival. Methyl laurate is a 12-carbon saturated fatty acid ester with a broad spectrum of bioactivities, including the activation of nuclear receptors. It has antimicrobial properties and is used as a flavoring agent. It has not undergone clinical trials and is not approved as a pharmaceutical. |
| Molecular Formula |
C13H26O2
|
|---|---|
| Molecular Weight |
214.34
|
| Exact Mass |
214.193
|
| CAS # |
111-82-0
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| PubChem CID |
8139
|
| Appearance |
Colorless to light yellow liquid
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| Density |
0.9±0.1 g/cm3
|
| Boiling Point |
263.0±3.0 °C at 760 mmHg
|
| Melting Point |
5.2 °C
; 5 °C
|
| Flash Point |
114.6±6.9 °C
|
| Vapour Pressure |
0.0±0.5 mmHg at 25°C
|
| Index of Refraction |
1.433
|
| LogP |
5.49
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
11
|
| Heavy Atom Count |
15
|
| Complexity |
144
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O(C([H])([H])[H])C(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O
|
| InChi Key |
UQDUPQYQJKYHQI-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C13H26O2/c1-3-4-5-6-7-8-9-10-11-12-13(14)15-2/h3-12H2,1-2H3
|
| Chemical Name |
methyl dodecanoate
|
| Synonyms |
Methyl laurate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (466.55 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (11.66 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (11.66 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (11.66 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6655 mL | 23.3274 mL | 46.6548 mL | |
| 5 mM | 0.9331 mL | 4.6655 mL | 9.3310 mL | |
| 10 mM | 0.4665 mL | 2.3327 mL | 4.6655 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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