| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
1-Pentadecanol does not have a defined biological target. It exhibits antimicrobial activity, especially against Propionibacterium acnes. It shows potential activity in the ER agonist pathway. Long-chain fatty alcohols have been reported to lower plasma cholesterol in humans. The compound's antimicrobial mechanism is likely related to membrane disruption.
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|---|---|
| ln Vitro |
In vitro, 1-pentadecanol shows potent antimicrobial activity against Propionibacterium acnes with a minimum inhibitory concentration (MIC) of 0.78 µg/mL and a minimum bactericidal concentration (MBC) of 1.56 µg/mL. At a concentration of 25 µg/mL, it demonstrates a reduction greater than 2.0 log units in CFU/mL at the lag growth phase after 48 hours. In contrast, it is not effective against Staphylococcus aureus, exhibiting an MIC of greater than 800.0 µg/mL.
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| ln Vivo |
1-Pentadecanol is not a pharmacologically approved drug. It is a natural product with anti-acne activity. Its in vivo activity has not been established in clinical settings. It is used primarily as a research compound and analytical standard.
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| Enzyme Assay |
In vitro assays for 1-pentadecanol typically involve antimicrobial susceptibility testing. A standard protocol involves culturing Propionibacterium acnes in appropriate media and treating with varying concentrations of 1-pentadecanol (typically 0.1-100 µg/mL). The MIC and MBC are determined by broth microdilution methods. Cell viability is assessed by colony counting.
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| Cell Assay |
In vitro cell culture experiments with 1-pentadecanol are not standard, as it is primarily an antimicrobial research compound. When studying its effects, bacterial cells are treated with the compound, and growth inhibition is measured.
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| Animal Protocol |
In vivo animal studies with 1-pentadecanol are not well documented. It is used primarily as a research compound and analytical standard.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of 1-pentadecanol are not characterized, as it is not a drug substance. Based on its physicochemical properties (molecular weight 228.41, soluble in DMSO at 30 mg/mL), the compound would be expected to have moderate bioavailability. However, it is not intended for human exposure.
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| Toxicity/Toxicokinetics |
1-Pentadecanol has low toxicity, but overexposure can cause CNS depression and prolonged skin contact causes irritation. Aliphatic alcohols are metabolized and eliminated efficiently. Standard laboratory safety precautions should be followed when handling this compound, including the use of gloves and safety glasses.
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| References | |
| Additional Infomation |
Pentadecanol is a colorless liquid with a slightly alcoholic odor and floats on water. (US Coast Guard, 1999)
Pentadecan-1-ol is a long-chain fatty alcohol formed by replacing a terminal methyl hydrogen atom in a pentadecane molecule with a hydroxyl group. It is a long-chain primary fatty alcohol and also a Pentadecanol. It has been reported that 1-pentadecanyl alcohol is found in angelica, peach leaf buds, and other organisms with relevant data. See also: Alcohols, C12-18 (Note moved here). 1-Pentadecanol is a naturally occurring long-chain fatty alcohol with anti-acne activity. It shows potent antimicrobial activity against Propionibacterium acnes. It has not undergone clinical trials and is not approved as a pharmaceutical. |
| Molecular Formula |
C15H32O
|
|---|---|
| Molecular Weight |
228.41
|
| Exact Mass |
228.245
|
| CAS # |
629-76-5
|
| Related CAS # |
1-Pentadecanol-d31; 349553-87-3
|
| PubChem CID |
12397
|
| Appearance |
White to off-white solid
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| Density |
0.8±0.1 g/cm3
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| Boiling Point |
298.5±3.0 °C at 760 mmHg
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| Melting Point |
111 °F (USCG, 1999)
; 45 - 46 °C
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| Flash Point |
130.1±4.6 °C
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| Vapour Pressure |
0.0±1.4 mmHg at 25°C
|
| Index of Refraction |
1.447
|
| LogP |
6.72
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
13
|
| Heavy Atom Count |
16
|
| Complexity |
112
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
|
| InChi Key |
REIUXOLGHVXAEO-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C15H32O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16/h16H,2-15H2,1H3
|
| Chemical Name |
pentadecan-1-ol
|
| Synonyms |
1-Pentadecanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 33.33 mg/mL (145.92 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.95 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.95 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.3781 mL | 21.8905 mL | 43.7809 mL | |
| 5 mM | 0.8756 mL | 4.3781 mL | 8.7562 mL | |
| 10 mM | 0.4378 mL | 2.1890 mL | 4.3781 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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