| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
Taxifolin 7-O-β-D-glucoside targets various pathways involved in plant defense and metabolism. As a flavonoid, it may interact with reactive oxygen species (ROS) and serve as an antioxidant. Its targets in biological systems are primarily related to its role as a secondary metabolite in plants, where it provides protection against environmental stressors. The compound's specific molecular targets in mammalian systems have not been extensively characterized.
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| ln Vitro |
In vitro activity studies for taxifolin 7-O-β-D-glucoside are limited, as the compound is primarily studied as a plant metabolite. It is a flavonoid that may exhibit antioxidant properties due to its phenolic hydroxyl groups. As a glycoside, it may be hydrolyzed to release the aglycone taxifolin, which has known antioxidant and anti-inflammatory activities. Further in vitro characterization is needed to define its biological activities.
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| ln Vivo |
In vivo activity data for taxifolin 7-O-β-D-glucoside are limited, as the compound is a plant metabolite rather than a therapeutic agent. It is produced during seed germination in Scutellaria baicalensis and functions to protect against pathogens and UV damage. Its in vivo effects in animal models have not been extensively studied.
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| Enzyme Assay |
Non-cellular assays for taxifolin 7-O-β-D-glucoside typically involve analytical characterization using techniques such as HPLC, LC-MS, and NMR spectroscopy. The compound's antioxidant capacity can be measured using standard in vitro assays such as DPPH or ABTS radical scavenging assays. These cell-free systems allow for the characterization of the compound's chemical properties and reactivity without cellular interference.
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| Cell Assay |
Cellular assays for taxifolin 7-O-β-D-glucoside have not been extensively reported in the literature. As a plant metabolite, it is primarily studied in the context of plant physiology rather than mammalian cell systems. Future studies may investigate its effects on mammalian cell lines to explore potential pharmacological activities such as antioxidant, anti-inflammatory, or cytoprotective effects.
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| Animal Protocol |
In vivo animal experiments for taxifolin 7-O-β-D-glucoside are not typically conducted, as the compound is a plant metabolite rather than a therapeutic agent. Its biological functions are studied in the context of plant physiology and seed germination. Animal studies would be needed to explore potential pharmacological applications, but such studies have not been extensively reported.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of taxifolin 7-O-β-D-glucoside are not well-characterized, as the compound is a plant metabolite rather than a pharmaceutical compound. As a glycoside with molecular weight 466.39 g/mol, it may have limited oral bioavailability due to poor membrane permeability. The compound may be hydrolyzed by intestinal glycosidases to release the aglycone taxifolin. Storage conditions and stability data are available from chemical suppliers.
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| Toxicity/Toxicokinetics |
Toxicological data for taxifolin 7-O-β-D-glucoside are limited, as the compound is a natural plant metabolite rather than a pharmaceutical compound. As a flavonoid glycoside, it is generally considered to have low toxicity. Standard laboratory safety precautions should be followed when handling the compound. No significant toxicity has been reported for this compound in the literature.
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| References | |
| Additional Infomation |
According to reports, dodder, red pine, and other organisms with available data contain taxonomic 7-glucoside.
Other information includes the compound's role as a main metabolite at the seed germination stage in Scutellaria baicalensis. It is a flavonoid that is mainly found in the endosperm and functions to defend against pathogens and UV damage. The compound is also known as taxifolin 7-O-glucoside and has the CAS number 14292-40-1. It is used as a reference standard in analytical chemistry and natural product research. |
| Molecular Formula |
C21H22O12
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|---|---|
| Molecular Weight |
466.39
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| Exact Mass |
466.111
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| CAS # |
14292-40-1
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| PubChem CID |
14282775
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| Appearance |
White to yellow solid
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| LogP |
-0.3
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| Hydrogen Bond Donor Count |
8
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| Hydrogen Bond Acceptor Count |
12
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
33
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| Complexity |
692
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| Defined Atom Stereocenter Count |
7
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| SMILES |
C1=CC(=C(C=C1C2C(C(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)O)O)O)O)O
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| InChi Key |
BJAHHJOBSKZTFE-JUIPTLLLSA-N
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| InChi Code |
InChI=1S/C21H22O12/c22-6-13-15(26)17(28)19(30)21(33-13)31-8-4-11(25)14-12(5-8)32-20(18(29)16(14)27)7-1-2-9(23)10(24)3-7/h1-5,13,15,17-26,28-30H,6H2/t13-,15-,17+,18+,19-,20-,21-/m1/s1
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| Chemical Name |
(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3-dihydrochromen-4-one
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| Synonyms |
Taxifolin 7-O-glucoside; Taxifolin 7-O-β-D-glucoside
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (214.41 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (5.36 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.36 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: 2.5 mg/mL (5.36 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1441 mL | 10.7206 mL | 21.4413 mL | |
| 5 mM | 0.4288 mL | 2.1441 mL | 4.2883 mL | |
| 10 mM | 0.2144 mL | 1.0721 mL | 2.1441 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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