| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
2,5-Furandimethanol does not have a defined pharmacological receptor target. Its biological activities are attributed to its chemical properties as a furan derivative. It has demonstrated effects on leukemia cells and is used in fungal infection research.
|
|---|---|
| ln Vitro |
2,5-Furandimethanol exhibits antioxidant and antibacterial activity. It affects leukemia cells, suggesting potential anti-cancer properties. The compound's activities are likely related to its ability to interact with cellular redox systems and microbial membranes, though the exact mechanisms have not been fully elucidated. 5-hydroxymethylfurfural, as a building block, is considered an important intermediate due to its rich chemistry and potential availability from carbohydrates such as fructose, glucose, sucrose, cellulose and inulin.
|
| ln Vivo |
In vivo activity data for 2,5-Furandimethanol are limited. It has been shown to affect leukemia in experimental models, but detailed in vivo studies are not available in the published literature.
|
| Enzyme Assay |
Not applicable; 2,5-Furandimethanol is not evaluated in classical receptor binding assays. Its antioxidant activity can be assessed using standard radical scavenging assays such as DPPH or ABTS. Antibacterial activity is evaluated using agar diffusion or broth microdilution methods against bacterial and fungal pathogens.
|
| Cell Assay |
The effects of 2,5-Furandimethanol on leukemia cells can be evaluated in leukemia cell lines by measuring cell viability, proliferation, and apoptosis. Antibacterial and antifungal activities are assessed using standard microbiological techniques.
|
| Animal Protocol |
In vivo studies of 2,5-Furandimethanol would typically involve xenograft models of leukemia or infection models to evaluate its anti-cancer or anti-infective potential. However, specific protocols have not been reported in the available literature.
|
| ADME/Pharmacokinetics |
Pharmacokinetic data for 2,5-Furandimethanol have not been reported. As a small molecule, its absorption, distribution, metabolism, and excretion would depend on its physicochemical properties.
|
| Toxicity/Toxicokinetics |
No specific toxicity data have been reported for 2,5-Furandimethanol. As a biomass-derived compound, it is considered to have a favorable environmental profile. Standard laboratory safety precautions should be followed.
|
| References | |
| Additional Infomation |
2,5-Furfural is a furan compound with hydroxymethyl substituents at positions 2 and 5. It belongs to the furan class and is also a diol. 2,5-Furfural has been reported to have been found in Clostridium wallichthys, and relevant data are available for reference.
2,5-Furandimethanol is a research compound, not an approved drug. It is primarily used as a building block for sustainable chemistry applications, including the synthesis of bio-based polyesters and drug intermediates. Its bio-based origin makes it valuable for green chemistry research. The compound is also used as a solvent and in the synthesis of nucleoside derivatives and crown ethers. |
| Molecular Formula |
C6H8O3
|
|---|---|
| Molecular Weight |
128.13
|
| Exact Mass |
128.047
|
| CAS # |
1883-75-6
|
| PubChem CID |
74663
|
| Appearance |
Light yellow to brown solid
|
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
275.4±30.0 °C at 760 mmHg
|
| Melting Point |
74-77 ℃
|
| Flash Point |
120.3±24.6 °C
|
| Vapour Pressure |
0.0±0.6 mmHg at 25°C
|
| Index of Refraction |
1.543
|
| LogP |
-0.99
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
9
|
| Complexity |
74.4
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O1C(C([H])([H])O[H])=C([H])C([H])=C1C([H])([H])O[H]
|
| InChi Key |
DSLRVRBSNLHVBH-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C6H8O3/c7-3-5-1-2-6(4-8)9-5/h1-2,7-8H,3-4H2
|
| Chemical Name |
[5-(hydroxymethyl)furan-2-yl]methanol
|
| Synonyms |
2,5-Furandimethanol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O: 100 mg/mL (780.46 mM)
DMSO: 50 mg/mL (390.23 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (19.51 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (19.51 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.8046 mL | 39.0229 mL | 78.0457 mL | |
| 5 mM | 1.5609 mL | 7.8046 mL | 15.6091 mL | |
| 10 mM | 0.7805 mL | 3.9023 mL | 7.8046 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
