| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
| Targets |
Linoleyl alcohol does not have a defined pharmacological receptor target, as it is primarily a lipid standard and chemical building block rather than a therapeutic agent. As a fatty alcohol, it may interact with lipid membranes and be incorporated into lipid bilayers. Its primary applications are in analytical chemistry and lipid research, where it serves as a reference standard for lipid analysis. No specific receptor binding or enzyme inhibition activities have been reported.
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|---|---|
| ln Vitro |
Potato tuber lipoxygenase dioxygenates linalyl alcohol to form two positional isomeric products, 9- and 13-hydroperoxyoctadecadien-1-ols[1].
In vitro, linoleyl alcohol serves as a non-ionizable substrate for oxidation detection. It is used as a building block for the synthesis of lipid-based unsymmetrical O,O-dialkylphosphites. As a polyunsaturated fatty alcohol, it may be subject to oxidation and can be used to study lipid peroxidation processes. No specific pharmacological activities, such as receptor binding or enzyme inhibition, have been reported for this compound. Its primary in vitro utility is as a chemical standard and synthetic intermediate. |
| ln Vivo |
Esters derived from gallic acid (GA) and (-)-Epigallo-catechin (EGC) or linalyl alcohol have been shown in animal feeding experiments to be more effective than intact GA and EGC in promoting weight loss and managing metabolic syndrome[2].
No in vivo pharmacological activity has been reported for linoleyl alcohol, as it is not intended for therapeutic use. Its applications are confined to analytical chemistry and lipid research, where it serves as a reference standard for the quantification of fatty alcohols in biological samples. The compound is a lipid standard used in research settings and is not administered to animals as a test article for pharmacological evaluation. |
| Enzyme Assay |
Non-cellular assays for linoleyl alcohol would typically involve analytical chemistry methods such as GC, HPLC, or mass spectrometry to quantify the compound in various matrices. As a lipid standard, it is used in the development and validation of analytical methods for fatty alcohol analysis. Its oxidation can be studied using spectrophotometric or chromatographic methods to evaluate lipid peroxidation. No receptor binding or enzyme inhibition assays are performed with this compound.
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| Cell Assay |
Cell-based assays are not typically performed with linoleyl alcohol as a test article. It may be used in cell culture studies as a lipid supplement or to study the effects of fatty alcohols on cellular processes. However, specific cell-based protocols for this compound are not documented in the available literature. Its primary use in a research setting is as an analytical standard and chemical building block rather than as a directly testable compound in cell-based assays.
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| Animal Protocol |
In vivo animal studies are not conducted with linoleyl alcohol as a primary test agent. It is used as a reference standard in analytical chemistry applications and as a building block for chemical synthesis. The compound is not a therapeutic agent and is not administered to animals for pharmacological evaluation. Its role in research is strictly as a chemical standard and synthetic intermediate.
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| ADME/Pharmacokinetics |
Metabolism / Metabolites
The known metabolites of linoleol include linoleoyl O-glucuronide. Pharmacokinetic data are not applicable for linoleyl alcohol, as it is not a drug candidate. The compound has a molecular weight of 266.47 g/mol and is a lipophilic fatty alcohol. It is soluble in DMF (15 mg/ml), DMSO (10 mg/ml), and ethanol (10 mg/ml), with limited aqueous solubility. No pharmacokinetic parameters have been characterized for this compound, as it is a research chemical and lipid standard rather than a therapeutic agent. |
| Toxicity/Toxicokinetics |
No toxicity data have been reported for linoleyl alcohol in the available literature. As a fatty alcohol, it is generally considered to have low toxicity. The compound is not for human or veterinary use. Standard laboratory safety precautions should be followed when handling this compound. Its safety profile has not been extensively characterized.
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| References | |
| Additional Infomation |
(9Z,12Z)-Octadecadien-1-ol is a long-chain fatty alcohol, an octadecyl alcohol containing two double bonds located at positions 9 and 12 (9Z,12Z-geometric isomers). It is a long-chain primary fatty alcohol and also an 18:2 fatty alcohol. (9Z,12Z)-Octadecadien-9,12-dien-1-ol has been reported in Bidens aurea, and relevant data are available.
Linoleyl alcohol is a research chemical and lipid standard, not an approved pharmaceutical drug. It is a polyunsaturated fatty alcohol used as a building block in the synthesis of lipid-based compounds and as a non-ionizable substrate for oxidation detection. The compound is a high-purity reference standard for lipid analysis and is used in analytical chemistry applications. It is not intended for human therapeutic use and is for research purposes only. |
| Molecular Formula |
C18H34O
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|---|---|
| Molecular Weight |
266.46
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| Exact Mass |
266.26
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| CAS # |
506-43-4
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| PubChem CID |
5365682
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
374.0±11.0 °C at 760 mmHg
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| Flash Point |
124.1±15.6 °C
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| Vapour Pressure |
0.0±1.9 mmHg at 25°C
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| Index of Refraction |
1.473
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| LogP |
7.28
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
14
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| Heavy Atom Count |
19
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| Complexity |
206
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C(/[H])=C(/[H])\C([H])([H])/C(/[H])=C(/[H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
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| InChi Key |
JXNPEDYJTDQORS-HZJYTTRNSA-N
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| InChi Code |
InChI=1S/C18H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h6-7,9-10,19H,2-5,8,11-18H2,1H3/b7-6-,10-9-
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| Chemical Name |
(9Z,12Z)-octadeca-9,12-dien-1-ol
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| Synonyms |
Linoleyl alcohol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (375.29 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.38 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (9.38 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.38 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7529 mL | 18.7645 mL | 37.5291 mL | |
| 5 mM | 0.7506 mL | 3.7529 mL | 7.5058 mL | |
| 10 mM | 0.3753 mL | 1.8765 mL | 3.7529 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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