| Size | Price | |
|---|---|---|
| Other Sizes |
| ln Vitro |
Ferrous bisglycinate (25–200 μM; 2 h) has no effect on the viability of Caco-2 cells[2]. The Caco-2 cells' ferritin level is increased by ferrous bisglycinate (25 μM; 2 h)[2].
|
|---|---|
| ln Vivo |
Mice treated with ferrous bisglycinate (500 mg/kg iron; po) do not develop colitis[3].
|
| Cell Assay |
Cell Viability Assay[2]
Cell Types: Caco-2 cells Tested Concentrations: 0, 25, 50, 100, 200 μM Incubation Duration: 2 hrs (hours) Experimental Results: Did not affect the viability of wild-type and divalent metal transporter 1 (DMT1) knockout Caco-2 cells . Western Blot Analysis[2] Cell Types: Caco-2 cells Tested Concentrations: 25 μM Incubation Duration: 2 hrs (hours) Experimental Results: Increased ferritin content and diminished DMT1 expression levels Dramatically in the wild-type cells. |
| Animal Protocol |
Animal/Disease Models: Female C57BL/6 mice are induced colitis by dextran sodium sulfate (DSS)[3]
Doses: 500 mg/kg iron Route of Administration: Po (add to the diet) for 10 days Experimental Results: Had the best survival rates (100%). Caused the least body lost (9% body loss). |
| References |
|
| Additional Infomation |
Ferrous bisglycinate is a chelate that is used as a source of dietary iron. Forming a ring structure when reacting with glycine, ferrous bisglycinate acts as both a chelate and a nutritionally functional. It is found in foods for food enrichment or in supplements for the treatment of iron deficiency or iron deficiency anemia.
See also: ... View More ... |
| Molecular Formula |
C4H6FEN2O4
|
|---|---|
| Molecular Weight |
201.95
|
| Exact Mass |
203.983
|
| CAS # |
20150-34-9
|
| PubChem CID |
9837124
|
| Appearance |
Light brown to green solid powder
|
| Boiling Point |
240.9ºC at 760 mmHg
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
11
|
| Complexity |
37.4
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
GIPOFCXYHMWROH-UHFFFAOYSA-L
|
| InChi Code |
InChI=1S/2C2H5NO2.Fe/c2*3-1-2(4)5;/h2*1,3H2,(H,4,5);/q;;+2/p-2
|
| Chemical Name |
2-aminoacetate;iron(2+)
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
0.1 M HCL: 2 mg/mL (9.90 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2 mg/mL (9.90 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.9517 mL | 24.7586 mL | 49.5172 mL | |
| 5 mM | 0.9903 mL | 4.9517 mL | 9.9034 mL | |
| 10 mM | 0.4952 mL | 2.4759 mL | 4.9517 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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