| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
The primary targets of γ-Glutamyl-S-allylcysteine are not specific receptors but rather its interaction with reactive molecules and pathways. It acts as an antioxidant by scavenging free radicals and chelating metal ions. It has an antiglycative effect, which may involve the inhibition of advanced glycation end-product (AGE) formation.
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| ln Vitro |
γ-Glutamyl-S-allylcysteine (0.1-2.5 mg/mL) decreases reactive free lysine side chains in a concentration-dependent manner and prevents the increase in fluorescence intensity at about 440 nm [1]. The glycation-specific decrease in BSA α-helical content and the increase in β-sheets in vitro are prevented by γ-glutamyl-S-allylcysteine (2.5 mg/mL) [1]. [1] γ-Glutamyl-S-allylcysteine (2.5 mg/mL) prevents the formation of polymers by blocking protein cross-linking. The compound γ-glutamyl-S-allylcysteine (10, 40, and 160 μg/mL) can chelate metals and scavenge free radicals [1].
In vitro, γ-Glutamyl-S-allylcysteine demonstrates free radical scavenging and metal-chelating capacities. It decreases glycation and provides structural protection to proteins. These activities are attributed to its sulfur-containing chemical structure. |
| ln Vivo |
In vivo, γ-Glutamyl-S-allylcysteine is a major organosulfur compound in garlic that contributes to its health-promoting effects. Its antioxidant and antiglycation properties may help protect against oxidative damage and age-related diseases. It is a subject of interest for its potential role in preventing chronic diseases.
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| Enzyme Assay |
Non-cellular assays for γ-Glutamyl-S-allylcysteine involve measuring its antioxidant activity using DPPH or ABTS radical scavenging assays. Metal-chelating activity can be assessed using standard spectrophotometric methods. Antiglycation activity is measured by its ability to inhibit the formation of AGEs in protein-sugar models.
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| Cell Assay |
Cellular assays for γ-Glutamyl-S-allylcysteine are conducted using cell lines to assess its cytoprotective effects. Cells are treated with the compound, and its ability to reduce intracellular reactive oxygen species (ROS) and protect against oxidative stress-induced damage is measured.
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| Animal Protocol |
In vivo animal experiments for γ-Glutamyl-S-allylcysteine are conducted in models of oxidative stress, diabetes, or aging. The compound is administered orally, and its effects on markers of oxidative stress, glycation, and inflammation are assessed in various tissues.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of γ-Glutamyl-S-allylcysteine are not well-characterized. As a γ-glutamyl peptide, it may be metabolized by enzymes such as γ-glutamyl transferase. Its absorption and bioavailability after oral consumption are areas of ongoing research.
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| Toxicity/Toxicokinetics |
Toxicological data for γ-Glutamyl-S-allylcysteine are limited, as it is a natural compound found in garlic. It is generally considered safe for consumption at dietary levels. Standard laboratory safety precautions should be followed when handling the compound in its purified form.
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| References |
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| Additional Infomation |
Garlic (Allium sativum) is reported to contain γ-glutamyl-S-allylcysteine, and relevant data is available. See also: Garlic (partial).
γ-Glutamyl-S-allylcysteine is a bioactive organosulfur compound from garlic. It is a subject of research for its potential therapeutic applications in oxidative stress-related diseases, metabolic disorders, and aging. It is often used as a reference compound in studies of garlic's health benefits. |
| Molecular Formula |
C11H18N2O5S
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|---|---|
| Molecular Weight |
290.34
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| Exact Mass |
290.094
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| CAS # |
91216-95-4
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| PubChem CID |
11346811
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| Appearance |
White to off-white solid
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| LogP |
1.207
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
10
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| Heavy Atom Count |
19
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| Complexity |
348
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| Defined Atom Stereocenter Count |
2
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| SMILES |
C=CCSCC(C(=O)O)NC(=O)CCC(C(=O)O)N
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| InChi Key |
FUTHBNRZCFKVQZ-YUMQZZPRSA-N
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| InChi Code |
InChI=1S/C11H18N2O5S/c1-2-5-19-6-8(11(17)18)13-9(14)4-3-7(12)10(15)16/h2,7-8H,1,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8-/m0/s1
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| Chemical Name |
(2S)-2-amino-5-[[(1R)-1-carboxy-2-prop-2-enylsulfanylethyl]amino]-5-oxopentanoic acid
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| Synonyms |
L-γ-Glutamyl-(S)-Allyl-Cysteine; γ-Glutamyl-S-allylcysteine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O: 33.33 mg/mL (114.80 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: 25 mg/mL (86.11 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4442 mL | 17.2212 mL | 34.4424 mL | |
| 5 mM | 0.6888 mL | 3.4442 mL | 6.8885 mL | |
| 10 mM | 0.3444 mL | 1.7221 mL | 3.4442 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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