| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
There is no single specific biological target. Its applications are primarily in medicinal chemistry and as a building block. Its structural flexibility supports applications in ligand design and surface modification. It has been explored for potential biological activity, including antimicrobial and enzyme-inhibitory properties.
|
|---|---|
| ln Vitro |
Specific in vitro biological activity is not its primary use. It is a chemical intermediate. However, its primary and secondary amine groups can be used to synthesize compounds that are then tested for biological activity, such as antimicrobial or enzyme inhibition. The compound itself may have general base properties.
|
| ln Vivo |
No specific in vivo activity is reported for this compound itself, as it is a synthetic intermediate. Any in vivo effects would be associated with the final drug molecules or active compounds synthesized from it. It is not a therapeutic agent.
|
| Enzyme Assay |
As a reagent for organic synthesis, N-(3-Aminopropyl)cyclohexylamine is used in standard amide coupling reactions. A typical procedure involves reacting it with a carboxylic acid in the presence of a coupling agent (e.g., EDC or HATU) and a base to form the corresponding amide bond. The reaction can be carried out in a solvent like DMF or DCM.
|
| Cell Assay |
Cell-based assays are not applicable for this intermediate itself. Its role is in the synthesis of compounds that are later tested in cells. For example, a library of compounds synthesized using this amine could be screened for antimicrobial activity or enzyme inhibition in cellular models.
|
| Animal Protocol |
As a chemical intermediate, animal studies are not conducted with this compound. Its purpose is to be converted into other molecules that may subsequently be tested in vivo. The compound is not administered to animals for therapeutic or investigative purposes.
|
| ADME/Pharmacokinetics |
Pharmacokinetic data are not relevant for this chemical intermediate. Its physical properties are characterized: molecular weight 156.27 g/mol, boiling point 123 °C/20 mmHg, flash point 101 °C. It is a clear, colorless to light yellow liquid, soluble in DMSO, water, and PBS.
|
| Toxicity/Toxicokinetics |
Toxicological data for this compound are not typically detailed in general references. As an amine, it is likely an irritant and should be handled with care. It is classified as air-sensitive. Standard safety precautions for handling amines apply, including use in a fume hood with appropriate PPE.
|
| References |
[1]. P J Chu, et al.Antagonistic effect of N-(3-Aminopropyl)cyclohexylamine on neurotrophic action of spermine in primary cultured rat hippocampal and cerebellar neurons. Jpn J Pharmacol. 1995 Dec;69(4):311-5.
|
| Additional Infomation |
A Safety Data Sheet (SDS) should be consulted before use.
|
| Molecular Formula |
C9H20N2
|
|---|---|
| Molecular Weight |
156.27
|
| Exact Mass |
156.162
|
| CAS # |
3312-60-5
|
| PubChem CID |
18718
|
| Appearance |
Colorless to light yellow liquid（Density：0.917 g/cm3 ）
|
| Density |
0.9±0.1 g/cm3
|
| Boiling Point |
238.7±8.0 °C at 760 mmHg
|
| Melting Point |
−17-−15 °C(lit.)
|
| Flash Point |
112.3±22.0 °C
|
| Vapour Pressure |
0.0±0.5 mmHg at 25°C
|
| Index of Refraction |
1.484
|
| LogP |
1.27
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
11
|
| Complexity |
87.6
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1CCC(CC1)NCCCN
|
| InChi Key |
ITZPOSYADVYECJ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C9H20N2/c10-7-4-8-11-9-5-2-1-3-6-9/h9,11H,1-8,10H2
|
| Chemical Name |
N'-cyclohexylpropane-1,3-diamine
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O: 100 mg/mL (639.92 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (639.92 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.3992 mL | 31.9959 mL | 63.9918 mL | |
| 5 mM | 1.2798 mL | 6.3992 mL | 12.7984 mL | |
| 10 mM | 0.6399 mL | 3.1996 mL | 6.3992 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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