| Size | Price | Stock | Qty |
|---|---|---|---|
| 100g |
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| Other Sizes |
| Targets |
Zinc sulfate heptahydrate does not have a specific pharmacological "target". Its primary biological function is to provide bioavailable zinc ions (Zn2+), which are essential cofactors for over 300 enzymes and are critical for numerous biological processes, including immune function, protein synthesis, wound healing, DNA synthesis, and cell division. The compound's activity is therefore based on its ability to deliver zinc to the body or to cells in culture.
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|---|---|
| ln Vitro |
Zinc supplementation can be achieved with zinc sulfate heptahydrate. Overdosing may cause fatigue, headaches, vomiting fits, and stomach pain.
In vitro, zinc sulfate heptahydrate is used as a source of zinc ions in cell culture media. Zinc is an essential nutrient for cell growth and proliferation. Its activity is measured by its ability to support cell viability and proliferation in zinc-deficient media, or by its effect on zinc-dependent enzymes and transcription factors. |
| ln Vivo |
In vivo, zinc sulfate heptahydrate is used as an oral zinc supplement to treat or prevent zinc deficiency. When ingested, it dissociates to release zinc ions, which are absorbed in the small intestine and distributed throughout the body to fulfill various physiological roles. It is also used in intravenous formulations for parenteral nutrition.
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| Enzyme Assay |
Zinc sulfate heptahydrate is not evaluated through a specific enzyme/receptor binding assay. Its purity and zinc content are typically assessed by chemical analysis, such as titration with EDTA or atomic absorption spectroscopy. The compound's solubility and stability in various solutions are also characterized.
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| Cell Assay |
In cell culture, zinc sulfate heptahydrate is dissolved in sterile water or media to prepare a stock solution and added to cell culture media at concentrations typically ranging from 0.1 to 100 µM. The effect on cell viability, proliferation, or zinc-dependent enzyme activity is measured.
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| Animal Protocol |
Zinc sulfate heptahydrate is used in animal studies as a dietary supplement to investigate the effects of zinc status on health and disease. It is added to the feed or drinking water of rodents or other animals to modulate their zinc levels. Parameters such as growth, immune function, and tissue zinc concentrations are then measured.
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| ADME/Pharmacokinetics |
Zinc sulfate heptahydrate has a molecular weight of 287.56 g/mol and a molecular formula of ZnSO4·7H2O. It is a white, crystalline, odorless powder or granule. It is highly soluble in water. It is hygroscopic and should be stored in a tightly closed container to protect it from moisture.
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| Toxicity/Toxicokinetics |
Zinc sulfate heptahydrate is generally recognized as safe (GRAS) when used as a dietary supplement at recommended levels. However, high doses can cause gastrointestinal distress, including nausea, vomiting, and diarrhea. Chronic excessive intake can lead to copper deficiency. It is also a skin and eye irritant.
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| References | |
| Additional Infomation |
Zinc sulfate heptahydrate is the heptahydrate form of zinc sulfate. It is both a hydrate and a metal sulfate. It contains zinc sulfate.
See also: Zinc ion (with the active moiety)... See more... Zinc sulfate heptahydrate is a widely used chemical with diverse applications in medicine, agriculture, and industry. It is the most common form of zinc in dietary supplements. Its role as an essential nutrient makes it a critical component of cell culture media and animal feeds. It is not a drug in the traditional sense but an essential nutrient and a chemical reagent. |
| Molecular Formula |
H14O11SZN
|
|---|---|
| Molecular Weight |
287.55
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| Exact Mass |
285.954
|
| CAS # |
7446-20-0
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| Related CAS # |
7733-02-0 (Parent);23713-49-7 (Parent)
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| PubChem CID |
62640
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| Appearance |
White to off-white solid powder
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| Density |
1.957
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| Boiling Point |
330ºC at 760 mmHg
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| Melting Point |
100 °C
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| Hydrogen Bond Donor Count |
7
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| Hydrogen Bond Acceptor Count |
11
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
13
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| Complexity |
62.2
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O.O.O.O.O.O.O.[O-]S(=O)(=O)[O-].[Zn+2]
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| InChi Key |
RZLVQBNCHSJZPX-UHFFFAOYSA-L
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| InChi Code |
InChI=1S/H2O4S.7H2O.Zn/c1-5(2,3)4;;;;;;;;/h(H2,1,2,3,4);7*1H2;/q;;;;;;;;+2/p-2
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| Chemical Name |
zinc;sulfate;heptahydrate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O: 166.67 mg/mL (579.62 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.69 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.69 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (8.69 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4777 mL | 17.3883 mL | 34.7766 mL | |
| 5 mM | 0.6955 mL | 3.4777 mL | 6.9553 mL | |
| 10 mM | 0.3478 mL | 1.7388 mL | 3.4777 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Link: https://clinicaltrials.gov/ct2/show/NCT04765267
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