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| References | |
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| Additional Infomation |
β-D-glucose is d-glucose pyranose with a β-configuration of its anomeric carbon atom. It is an epitope and a metabolite in mice. It is the enantiomer of β-L-glucose. It is a major energy source for organisms. β-D-glucose is naturally found in fruits and other parts of plants, existing in a free state. It can be used for treatment with fluids and nutritional supplements.
Glucose oxidase has been studied for the treatment of upper respiratory tract infections. β-D-glucose is a metabolite found in or produced by Escherichia coli (K12 strain, MG1655 strain). (2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxacyclohexane-2,3,4,5-tetraol has been reported in hops, Acer rubrum, and other organisms with relevant data. β-D-glucose pyranose is the β-isomer of D-glucose pyranose, a simple synthetic monosaccharide that can be used as an energy source. D-glucan can be oxidized in various tissues under both aerobic and anaerobic conditions via glycolysis, producing carbon dioxide, water, and ATP. Yeast polysaccharide, an insoluble β-1,3-glucan derived from the yeast cell wall, is a structural component with potential immunostimulatory activity. After administration, yeast polysaccharide can target, bind to, and activate certain Toll-like receptors, primarily TLR2 on leukocytes and dectin-1 on macrophages. Activation of TLR2 and dectin-1 can stimulate the release of pro-inflammatory mediators and enhance the innate immune response. β-D-glucan is a metabolite found or produced in Saccharomyces cerevisiae. See also: Yeast polysaccharide (note moved to). |
| Molecular Formula |
(C6H10O5)N
|
|---|---|
| Molecular Weight |
504.43708
|
| Exact Mass |
504.169
|
| CAS # |
54724-00-4
|
| Related CAS # |
26874-89-5;133947-06-5
|
| PubChem CID |
64689
|
| Appearance |
White to yellow solid powder
|
| Density |
1.8±0.1 g/cm3
|
| Boiling Point |
902.8±65.0 °C at 760 mmHg
|
| Flash Point |
499.8±34.3 °C
|
| Vapour Pressure |
0.0±0.6 mmHg at 25°C
|
| Index of Refraction |
1.673
|
| LogP |
-6.08
|
| Hydrogen Bond Donor Count |
5
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
12
|
| Complexity |
151
|
| Defined Atom Stereocenter Count |
5
|
| SMILES |
C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
|
| InChi Key |
WQZGKKKJIJFFOK-VFUOTHLCSA-N
|
| InChi Code |
InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
|
| Chemical Name |
(2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 10 mg/mL
0.1 M NaOH: 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9824 mL | 9.9120 mL | 19.8240 mL | |
| 5 mM | 0.3965 mL | 1.9824 mL | 3.9648 mL | |
| 10 mM | 0.1982 mL | 0.9912 mL | 1.9824 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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