| Size | Price | Stock | Qty |
|---|---|---|---|
| 25mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
Purity: ≥95%
| Targets |
Fetuin targets the insulin receptor and other cell surface molecules. It binds to the insulin receptor and inhibits insulin action. It also promotes cell attachment, growth, and differentiation by interacting with cell surface receptors.
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|---|---|
| ln Vitro |
In many serum-free media, fetain, or fetal bovine serum, is a crucial addition[2]. ?Fetuin is an acidic glycoprotein that consists of three O- and N-linked oligosaccharide chains. Its net negative charge is attributed to the abundance of sialic acid (N-acetylneuramine acid) in its terminal sugar residues[3].
Fetuin is a glycoprotein that inhibits trypsin activity and promotes cell attachment, growth, and differentiation. Its in vitro activity is assessed by its ability to promote cell adhesion and growth in cell culture, or by its ability to inhibit insulin signaling in cell-based assays. |
| ln Vivo |
Fetuin is used as an additive in cell culture to promote cell adhesion and growth. It has been used in studies of type 2 diabetes mellitus (T2DM).
|
| Enzyme Assay |
The binding of Fetuin to the insulin receptor can be assessed using a receptor binding assay. The insulin receptor is immobilized on a solid support, and fetuin is added. The amount of fetuin bound is measured using a labeled detection reagent.
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| Cell Assay |
Fetuin is used as an additive in cell culture media to promote cell attachment, growth, and differentiation. It is added to serum-free or serum-reduced media to support the growth of various cell types.
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| Animal Protocol |
Fetuin is used in animal studies to study its role in type 2 diabetes mellitus and other metabolic diseases. The protein is administered to animals to study its effects on insulin signaling and glucose metabolism.
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| ADME/Pharmacokinetics |
Fetuin, Fetal Bovine Serum has a molecular weight of 64 kDa. It is a solid powder that is soluble in water (40 mg/mL). The protein should be stored at -20°C.
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| Toxicity/Toxicokinetics |
Toxicological data for Fetuin, Fetal Bovine Serum are not extensively detailed. It is a protein that is generally considered safe for research use. Standard laboratory safety precautions should be followed when handling the compound.
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| References | |
| Additional Infomation |
A class of calcium-binding α-globulins synthesized in the liver plays a crucial role in maintaining calcium solubility in the blood. Additionally, fetal globulins contain an N-terminal cystatin domain and are classified as cystatin type 3.
Fetuin, Fetal Bovine Serum is a widely used additive in cell culture to promote cell attachment and growth. It is also used in studies of type 2 diabetes mellitus and other metabolic diseases. The protein is not approved for therapeutic use and is strictly for laboratory research. |
| Molecular Formula |
N/A
|
|---|---|
| Molecular Weight |
N/A
|
| Exact Mass |
1137.914
|
| CAS # |
9014-81-7
|
| Related CAS # |
9002-81-7
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| PubChem CID |
167312532
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| Appearance |
White to off-white solid powder
|
| LogP |
20.2
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| Hydrogen Bond Donor Count |
6
|
| Hydrogen Bond Acceptor Count |
10
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| Rotatable Bond Count |
58
|
| Heavy Atom Count |
81
|
| Complexity |
1620
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CCCCCC=CCC=CCCCCCCCCCC(=O)OCCCCCCCCCCCC=CCC=CCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)O)O)O)C(C=CCCC=CCCC=CC)O
|
| InChi Key |
XZDRNDBKYKTHMT-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C70H123NO10/c1-3-5-7-9-11-13-14-15-16-28-32-35-38-42-46-50-54-58-66(75)79-59-55-51-47-43-39-36-33-30-27-25-23-21-19-17-18-20-22-24-26-29-31-34-37-41-45-49-53-57-65(74)71-62(63(73)56-52-48-44-40-12-10-8-6-4-2)61-80-70-69(78)68(77)67(76)64(60-72)81-70/h4,6,11-13,15-18,21,23,40,52,56,62-64,67-70,72-73,76-78H,3,5,7-10,14,19-20,22,24-39,41-51,53-55,57-61H2,1-2H3,(H,71,74)
|
| Chemical Name |
[30-[[3-hydroxy-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxytetradeca-4,8,12-trien-2-yl]amino]-30-oxotriaconta-12,15-dienyl] icosa-11,14-dienoate
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O: 50 mg/mL
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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