| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
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| ln Vitro |
When SNAC is at 200 μg/mL, the survival rate is over 90% and it has no cytotoxicity against Caco-2 (12.5-400 μg/mL; 24 h) [3]. The apparent permeability coefficient (Papp) of RA and SA-B can be increased by 2.14 and 3.68 times, respectively, by SNAC (50 and 200 μg/mL) in comparison to Papp of SAs solution [3].
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|---|---|
| ln Vivo |
In rats, SNAC enhances R1 and SAs' oral absorption and raises their bioavailability[3]. Only 20% of men and 50% of women died from SNAC (2000 mg/kg/d; oral gavage for 13 weeks)-related deaths, with no obvious reason given for the deaths[1]. Wistar rats were given oral gavage of SNAC at a dose of up to 1000 mg/kg/day for 13 weeks[1].
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| Animal Protocol |
Animal/Disease Models: SD (Sprague-Dawley) rats (6-7 weeks)[1]
Doses: 2000 mg/kg/d Route of Administration: po (oral gavage) for 13 weeks Experimental Results: Induced 20% and 50% mortality in males and females at the dose of 2000 mg /kg/d. |
| References |
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| Additional Infomation |
Salcaprozate Sodium is the sodium salt form of salcaprozate, an oral absorption promoter. Salcaprozate sodium may be used as a delivery agent to promote the oral absorption of certain macromolecules with poor bioavailability such as insulin and heparin.
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| Molecular Formula |
C15H20NNAO4
|
|---|---|
| Molecular Weight |
301.31
|
| Exact Mass |
301.128
|
| CAS # |
203787-91-1
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| PubChem CID |
23669833
|
| Appearance |
White to off-white solid powder
|
| Boiling Point |
521.7ºC at 760 mmHg
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| Flash Point |
269.3ºC
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| Vapour Pressure |
1.03E-11mmHg at 25°C
|
| LogP |
1.603
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| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
9
|
| Heavy Atom Count |
21
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| Complexity |
312
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
UOENJXXSKABLJL-UHFFFAOYSA-M
|
| InChi Code |
InChI=1S/C15H21NO4.Na/c17-13-9-6-5-8-12(13)15(20)16-11-7-3-1-2-4-10-14(18)19;/h5-6,8-9,17H,1-4,7,10-11H2,(H,16,20)(H,18,19);/q;+1/p-1
|
| Chemical Name |
sodium;8-[(2-hydroxybenzoyl)amino]octanoate
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 50 mg/mL (165.94 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.30 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.30 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (8.30 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3188 mL | 16.5942 mL | 33.1884 mL | |
| 5 mM | 0.6638 mL | 3.3188 mL | 6.6377 mL | |
| 10 mM | 0.3319 mL | 1.6594 mL | 3.3188 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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