| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
Natural product
2-(2-Phenylethyl)chromone targets various biological pathways through its chromone core. Chromones are known to interact with enzymes such as kinases, cyclooxygenases, and lipoxygenases. The compound may exhibit anti-inflammatory activity through inhibition of COX or LOX enzymes. Its antioxidant activity suggests interactions with oxidative stress pathways. Its anticancer activity may involve inhibition of cell proliferation and induction of apoptosis. The phenylethyl substituent may influence its biological activity and target interactions. Further research is needed to identify its specific molecular targets. |
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| ln Vitro |
Two new compounds 6,7-dimethoxy-2-[2-(2'-hydroxyphenyl)ethyl]chromone (1) and 6,7-dimethoxy-2-[2-(4'-hydroxyphenyl)ethenyl]chromone (2), together with ten known 2-(2-phenylethyl)chromones (3-12) were isolated from the resinous wood of Aquilaria sinensis (Lour.) Gilg. Their structures were elucidated by detailed IR, MS, NMR spectroscopic analyses, and comparison with reported. The absolute configuration of 3 was confirmed by Cu Kα X-ray crystallographic experiment, and the X-ray crystallographic data of 3 were firstly reported. Compounds 2, 8, 10, and 11 exhibited strong ABTS•+ radical scavenging activity, with IC50 values of 12.3, 16.5, 12.1, and 34.7 μM, respectively.[Formula: see text].[1]
In vitro studies have demonstrated that 2-(2-Phenylethyl)chromone exhibits potential biological activities characteristic of chromone derivatives. Chromones are known for their anti-inflammatory, antioxidant, and anticancer activities. The compound's effects on enzyme activity have been evaluated in various in vitro systems. Its antioxidant activity has been assessed using cell-free systems such as DPPH radical scavenging assays. These in vitro findings support its potential applications in chromone research and drug discovery. |
| ln Vivo |
In vivo studies of 2-(2-Phenylethyl)chromone are limited, as the compound is primarily used as a research chemical. Chromone derivatives have been studied in animal models for their anti-inflammatory, antioxidant, and anticancer activities. However, comprehensive in vivo studies specifically targeting 2-(2-Phenylethyl)chromone are not well documented in the available literature. Further research is needed to fully characterize its in vivo pharmacokinetic and pharmacodynamic properties.
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| Enzyme Assay |
In vitro enzyme assays for 2-(2-Phenylethyl)chromone typically involve testing its activity against targets relevant to chromone derivatives. Enzyme inhibition assays are performed for targets such as kinases, cyclooxygenases, and lipoxygenases. Enzyme activity is measured using appropriate substrates and detection methods. Antioxidant activity is assessed using cell-free systems such as DPPH radical scavenging assays, ABTS assays, or ferric reducing antioxidant power (FRAP) assays. All assays are performed with appropriate controls and standardized protocols.
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| Cell Assay |
In vitro cell-based assays for 2-(2-Phenylethyl)chromone involve culturing cancer cell lines to evaluate its potential anticancer activity. Cells are treated with varying concentrations of the compound for specified durations (24-72 hours). Cell viability is assessed using MTT, CCK-8, or similar colorimetric assays. Apoptosis is quantified using flow cytometry with Annexin V/PI staining or via caspase activity measurements. For anti-inflammatory studies, cells are stimulated with inflammatory stimuli and cytokine production is measured by ELISA. All experiments are performed in triplicate with appropriate controls.
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| Animal Protocol |
In vivo animal experiments for 2-(2-Phenylethyl)chromone would be conducted to evaluate its anti-inflammatory, antioxidant, and anticancer activities. For anti-inflammatory studies, animals with induced inflammation would be treated and inflammatory markers measured. For antioxidant studies, animals would be administered the compound and markers of oxidative stress measured. For anticancer studies, tumor-bearing animals would be treated and tumor growth monitored. Parameters assessed would include body weight, organ weights, and histopathology. Control groups receiving vehicle alone would be included for comparison. All procedures comply with institutional animal care and use committee guidelines.
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| ADME/Pharmacokinetics |
The pharmacokinetic properties of 2-(2-Phenylethyl)chromone reflect its nature as a small chromone derivative. It has a molecular weight consistent with its structure. As a lipophilic molecule, it can cross biological membranes readily. The compound is expected to be metabolized through standard xenobiotic pathways in the liver, including cytochrome P450-mediated oxidation and conjugation reactions. Complete pharmacokinetic profiling including half-life, clearance, and bioavailability would require further systematic studies.
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| Toxicity/Toxicokinetics |
The toxicity profile of 2-(2-Phenylethyl)chromone has been evaluated in the context of its use as a research chemical. As a chromone derivative, it may have biological activities that should be carefully evaluated. Proper handling procedures including use of personal protective equipment are recommended when working with pure compound. The compound is not approved for human therapeutic use and is intended for research purposes only. Long-term toxicity studies would be needed to fully establish its safety profile. Chromone derivatives should be handled with caution due to potential biological activities.
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| References | |
| Additional Infomation |
2-(2-Phenylacetyl)chromone is a type of chromone compound characterized by the substitution of 2-phenylethyl groups at the 2-position. It is found in agarwood, an aromatic, resinous heartwood derived from certain trees of the genus Aquilaria. It is a plant metabolite. It belongs to both the chromone and benzene groups. Its function is related to chromones. Reports have indicated that 2-(2-phenylethyl)chromone has been detected in Malaysian agarwood (Aquilaria malaccensis), Imperata cylindrica (Imperata cylindrica), and Chinese agarwood (Aquilaria sinensis), and relevant data are available for reference.
2-(2-Phenylethyl)chromone (CAS# 61828-53-3), also known as Flidersiachromone, is a chromone derivative with a phenylethyl substituent at the 2 position. Chromones are a class of compounds known for various biological activities including anti-inflammatory, antioxidant, and anticancer properties. 2-(2-Phenylethyl)chromone is a natural product found in various plant species. It is used in research applications for studying chromone chemistry and biology. It is intended for research use only and is not for human therapeutic use. |
| Molecular Formula |
C17H14O2
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|---|---|
| Molecular Weight |
250.29
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| Exact Mass |
250.099
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| CAS # |
61828-53-3
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| PubChem CID |
441964
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| Appearance |
Off-white to gray solid
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| Density |
1.173g/cm3
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| Boiling Point |
393.1ºC at 760 mmHg
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| Melting Point |
90-91 °C
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| Flash Point |
176.3ºC
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| Index of Refraction |
1.605
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| LogP |
3.578
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
19
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| Complexity |
352
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1=CC=C(C=C1)CCC2=CC(=O)C3=CC=CC=C3O2
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| InChi Key |
VNZNWFQJBFLELF-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H14O2/c18-16-12-14(11-10-13-6-2-1-3-7-13)19-17-9-5-4-8-15(16)17/h1-9,12H,10-11H2
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| Chemical Name |
2-(2-phenylethyl)chromen-4-one
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| Synonyms |
Flidersiachromone; 2-(2-Phenylethyl)chromone; 61828-53-3; Flindersiachromone; flidersiachromone; 2-Phenethyl-4H-chromen-4-one; 2-(2-phenylethyl)chromen-4-one; 4H-1-Benzopyran-4-one, 2-(2-phenylethyl)-; CHEBI:5092; 2-(2-Phenylethyl)chromone
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (399.54 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.99 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.99 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.99 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9954 mL | 19.9768 mL | 39.9537 mL | |
| 5 mM | 0.7991 mL | 3.9954 mL | 7.9907 mL | |
| 10 mM | 0.3995 mL | 1.9977 mL | 3.9954 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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