| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
|
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| Other Sizes |
| Toxicity/Toxicokinetics |
Interactions
In adult female Wistar rats, pre-gavage administration of 16 or 256 μM/kg cyanamide, tetramethylthiuram disulfide (TMTD), tetramethylthiuram monosulfide (TMTM), zinc fumarate, or zineb, followed by intraperitoneal injection of 2 g/kg ethanol 90 minutes or 18 hours later, resulted in a significant increase in serum acetaldehyde levels within 90–240 minutes after ethanol administration (but this was not observed after 90 minutes of zineb treatment or 18 hours of low-dose cyanamide treatment). Pre-administration of ANTU or ANIT at doses within the LD50 range followed by the same time period did not affect serum acetaldehyde levels in rats receiving the same dose of ethanol. Oral administration of 16 μM/kg TMTM and TMTD resulted in an increase in serum acetaldehyde levels that could last up to 48 hours. The effects of cyanamide began to appear after 45 minutes. |
|---|---|
| References |
[1]. Coleman, et al. Vibrational spectra of thiuram sulfides. Normal coordinate analysis of tetramethylthiuram mono-, di-, and tetrasulfides. Journal of Polymer Science, Polymer Physics Edition.Volume: 12.Issue: 5.Pages: 1001-13.Journal.1974.
[2]. Yingtao Sun, et al. Synergistic Effect of Copper Sulfate and Tetramethylthiuram Monosulfide Induced Metal-Coordination Cross-Linking in Nitrile–Butadiene Rubber. 25 April 2021. |
| Additional Infomation |
Tetramethylthiuram monosulfide is a standardized chemical allergen. Its physiological effects are achieved through increased histamine release and cell-mediated immune responses.
|
| Molecular Formula |
C6H12N2S3
|
|---|---|
| Molecular Weight |
208.37
|
| Exact Mass |
208.016
|
| CAS # |
97-74-5
|
| PubChem CID |
7347
|
| Appearance |
Yellow powder
|
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
260.9±23.0 °C at 760 mmHg
|
| Melting Point |
107-111 °C(lit.)
|
| Flash Point |
111.6±22.6 °C
|
| Vapour Pressure |
0.0±0.5 mmHg at 25°C
|
| Index of Refraction |
1.641
|
| LogP |
0.87
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
11
|
| Complexity |
147
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
S=C(N(C)C)SC(N(C)C)=S
|
| InChi Key |
REQPQFUJGGOFQL-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C6H12N2S3/c1-7(2)5(9)11-6(10)8(3)4/h1-4H3
|
| Chemical Name |
dimethylcarbamothioyl N,N-dimethylcarbamodithioate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 250 mg/mL (1199.79 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (9.98 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (9.98 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.7992 mL | 23.9958 mL | 47.9916 mL | |
| 5 mM | 0.9598 mL | 4.7992 mL | 9.5983 mL | |
| 10 mM | 0.4799 mL | 2.3996 mL | 4.7992 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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