| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Stearyldiethanolamine targets microbial cells as an antimicrobial agent. As a non-ionic surfactant, it is used in the development of antimicrobial materials. The compound's long C18 stearyl chain and hydroxyethyl groups provide amphiphilic properties that allow it to interact with microbial cell membranes. It can act as an emulsifier, stabilizer, and conditioning agent. Its targets include microbial cell membranes where it exerts antimicrobial effects.
|
|---|---|
| ln Vitro |
In vitro studies have demonstrated that Stearyldiethanolamine is used in the development of antimicrobial materials. The compound's properties as a non-ionic surfactant have been characterized. It can act as an emulsifier, stabilizer, and conditioning agent. These in vitro studies provide foundational data for understanding the compound's utility in antimicrobial material development and formulation applications.
|
| ln Vivo |
In vivo studies of Stearyldiethanolamine are limited as the compound is primarily used in industrial applications rather than as a therapeutic agent. Its antimicrobial properties suggest potential for in vivo evaluation in antimicrobial material applications. The compound is used in the development of antimicrobial cling wrap and antimicrobial nonwovens. However, comprehensive pharmacological studies are not applicable as the compound is not a therapeutic agent.
|
| Enzyme Assay |
In vitro antimicrobial assays for Stearyldiethanolamine typically involve testing its antimicrobial activity against various bacterial strains. Antimicrobial activity is assessed using standard disc diffusion or broth microdilution methods to determine minimum inhibitory concentrations (MICs). The compound's purity (97%) and identity are confirmed using analytical chemistry methods such as nuclear magnetic resonance spectroscopy and mass spectrometry. All assays are performed with appropriate controls.
|
| Cell Assay |
In vitro cell-based assays for Stearyldiethanolamine involve culturing bacterial cells to evaluate its antimicrobial activity. Bacterial cells are treated with varying concentrations of the compound and cell viability is monitored. The compound's effects on bacterial growth and cell membrane integrity are assessed. All experiments are performed in triplicate with appropriate controls to ensure statistical reliability.
|
| Animal Protocol |
In vivo animal experiments for Stearyldiethanolamine would be conducted for toxicology and safety assessment. Animals would be administered the compound and observed for signs of toxicity. Parameters assessed would include body weight, organ weights, and histopathology. The compound's effects on skin and eye irritation would be evaluated for safety in formulation applications. Control groups receiving vehicle alone would be included for comparison.
|
| ADME/Pharmacokinetics |
The pharmacokinetic properties of Stearyldiethanolamine reflect its nature as a lipophilic tertiary amine. It has a molecular weight of 357.61 and the molecular formula C22H47NO2. The compound appears as a light yellow waxy solid with a melting point of 51°C and a boiling point of 300°C. It has a purity of 97%. As a lipophilic compound, it would be absorbed through the skin and distributed in lipid-rich tissues.
|
| Toxicity/Toxicokinetics |
Toxicity Summary
The expert panel concluded that the following 47 polyethylene glycol (PEG), cocoyl amine, and related ingredients are safe for use in cosmetics under current cosmetic application methods and concentrations, provided they are formulated into non-irritating products… PEG-2 stearylamine… Under specific conditions, they are safe for use in cosmetics. The toxicity profile of Stearyldiethanolamine has been evaluated in the context of its industrial use. The compound is considered to have non-toxic characteristics. It has a purity of 97%. Proper handling procedures including use of personal protective equipment are recommended when working with pure compound. The compound is not approved for human therapeutic use and is intended for industrial and research purposes only. |
| References |
[1]. Freshness-keeping film. WO2014142218A1.
|
| Additional Infomation |
Stearyldiethanolamine is safe... polyethylene glycol-2 stearamine...
Stearyldiethanolamine (CAS# 10213-78-2) is also known as N,N-bis(2-hydroxyethyl)stearylamine, PEG-2 Stearamine. It has the molecular formula C22H47NO2 and a molecular weight of 357.61. The compound is a tertiary amine with a long C18 stearyl chain. Stearyldiethanolamine is used in antimicrobial cling wrap and antimicrobial nonwovens. It acts as an emulsifier, stabilizer, and conditioning agent. The compound is a non-ionic antistatic agent. |
| Molecular Formula |
C22H47NO2
|
|---|---|
| Molecular Weight |
357.61
|
| Exact Mass |
357.36
|
| CAS # |
10213-78-2
|
| PubChem CID |
61494
|
| Appearance |
Typically exists as solid at room temperature
|
| Density |
0.9±0.1 g/cm3
|
| Boiling Point |
481.2±20.0 °C at 760 mmHg
|
| Melting Point |
51ºC
|
| Flash Point |
201.2±20.4 °C
|
| Vapour Pressure |
0.0±2.7 mmHg at 25°C
|
| Index of Refraction |
1.474
|
| LogP |
8.31
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
21
|
| Heavy Atom Count |
25
|
| Complexity |
230
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
|
| InChi Key |
NDLNTMNRNCENRZ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C22H47NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(19-21-24)20-22-25/h24-25H,2-22H2,1H3
|
| Chemical Name |
2-[2-hydroxyethyl(octadecyl)amino]ethanol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
Ethanol: 100 mg/mL (279.63 mM)
DMSO: 41.67 mg/mL (116.52 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.33 mg/mL (6.52 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 23.3 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.33 mg/mL (6.52 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 23.3 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7963 mL | 13.9817 mL | 27.9634 mL | |
| 5 mM | 0.5593 mL | 2.7963 mL | 5.5927 mL | |
| 10 mM | 0.2796 mL | 1.3982 mL | 2.7963 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
