| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| Other Sizes |
| Targets |
Multiple targets: cancer-related targets; microbial targets; neurological targets.
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|---|---|
| ln Vitro |
16-Epivoacarpine exhibits biological activities typical of indole alkaloids, including anticancer, antimicrobial, and neuroactive effects. It may inhibit cancer cell proliferation and induce apoptosis. The compound may also show antimicrobial activity against various pathogens.
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| ln Vivo |
In vivo studies of 16-epivoacarpine are limited. Indole alkaloids from Voacanga species have been studied for their anticancer and neuroactive properties.
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| Enzyme Assay |
Anticancer activity is assessed by cell viability assays using cancer cell lines. Antimicrobial activity is assessed by broth microdilution for MIC determination. Neuroactive effects are assessed in neuronal cell models.
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| Cell Assay |
In vivo studies for 16-epivoacarpine are limited. Potential animal models include tumor xenograft models for anticancer evaluation.
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| Animal Protocol |
Pharmacokinetic data for 16-epivoacarpine are limited. As an indole alkaloid, it is expected to have moderate lipophilicity.
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| ADME/Pharmacokinetics |
Specific toxicity data for 16-epivoacarpine are limited. Standard laboratory safety practices should be followed.
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| Toxicity/Toxicokinetics |
16-Epivoacarpine is an indole alkaloid natural product found in plants of the Apocynaceae family. Indole alkaloids are known for their diverse biological activities. It is for research use only.
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| References | |
| Additional Infomation |
Reports have indicated the presence of 16-epicarpine in Gelsemium elegans, and relevant data are available for reference.
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| Molecular Formula |
C21H24N2O4
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|---|---|
| Molecular Weight |
368.43
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| Exact Mass |
368.173
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| CAS # |
114027-38-2
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| PubChem CID |
13946382
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| Appearance |
White to off-white solid
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
548.9±50.0 °C at 760 mmHg
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| Flash Point |
285.8±30.1 °C
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| Vapour Pressure |
0.0±1.6 mmHg at 25°C
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| Index of Refraction |
1.707
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| Source |
Originated from plants: other families
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| LogP |
1.96
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
27
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| Complexity |
681
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| Defined Atom Stereocenter Count |
4
|
| SMILES |
O[C@]12C3=C(C4C=CC=CC=4N3)CC3C(C(=O)OC)(CO)[C@H](/C(=C/C)/CN31)C2
|
| InChi Key |
ZROBSNVANUBAJZ-LWKNIGJSSA-N
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| InChi Code |
InChI=1S/C21H24N2O4/c1-3-12-10-23-17-8-14-13-6-4-5-7-16(13)22-18(14)21(23,26)9-15(12)20(17,11-24)19(25)27-2/h3-7,15,17,22,24,26H,8-11H2,1-2H3/b12-3-/t15-,17-,20+,21+/m0/s1
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| Chemical Name |
methyl (1R,12S,13R,14S,15E)-15-ethylidene-1-hydroxy-13-(hydroxymethyl)-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4,6,8-tetraene-13-carboxylate
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| Synonyms |
16-epi-Voacarpine; 16-Epivoacarpine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~271.4 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.79 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.79 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7142 mL | 13.5711 mL | 27.1422 mL | |
| 5 mM | 0.5428 mL | 2.7142 mL | 5.4284 mL | |
| 10 mM | 0.2714 mL | 1.3571 mL | 2.7142 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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