| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Insect olfactory receptors (sex pheromone receptors).
|
|---|---|
| ln Vitro |
Tetradecyl acetate acts as a sex pheromone in Ctenopseustis obliquana females, attracting males for mating. It interacts with olfactory receptors on male moths, triggering behavioral responses that lead them toward the pheromone source. The compound exhibits nematicidal activity against Bursaphelenchus xylophilus at a concentration of 0.5 mg/mL (0.9% mortality after 48 hours). It also has antioxidative properties and genotoxic activity, possibly due to inhibition of transcriptional regulation.
|
| ln Vivo |
Tetradecyl acetate is used in vivo as a pest management tool to disrupt mating of pest species. By releasing the synthetic pheromone in agricultural settings, male moths are confused and unable to locate females for mating, thereby reducing pest populations. The compound's efficacy in mating disruption has been demonstrated in field studies. It also has a strong effect on voltage-dependent calcium channels and can act as a cyclase inhibitor.
|
| Enzyme Assay |
Pheromone activity is assessed using behavioral assays in wind tunnels or field settings. Male moths are exposed to tetradecyl acetate and their behavioral responses (e.g., upwind flight, source location) are recorded. Electroantennogram (EAG) assays measure the electrical response of male moth antennae to the compound. For nematicidal activity, the compound is tested against Bursaphelenchus xylophilus in vitro at various concentrations, and mortality is assessed after 48 hours.
|
| Cell Assay |
Cell-based assays for tetradecyl acetate are limited. For studying its effects on voltage-dependent calcium channels, cells expressing these channels can be used in patch-clamp electrophysiology studies. For genotoxicity assessment, standard in vitro genotoxicity assays such as the Ames test (bacterial reverse mutation assay) or the micronucleus test in cultured mammalian cells can be employed. The compound's effects on transcriptional regulation can be studied using reporter gene assays in appropriate cell lines.
|
| Animal Protocol |
In vivo studies for tetradecyl acetate focus on its pheromone activity in pest management. Field trials involve releasing the synthetic pheromone in agricultural or forested areas and monitoring pest population levels and mating disruption efficiency. Wind tunnel studies with live moths assess behavioral responses to the compound. For nematicidal activity, in vivo studies may involve treating plants or soil with the compound and assessing nematode infestation levels.
|
| ADME/Pharmacokinetics |
As a volatile pheromone compound, tetradecyl acetate is used in pheromone dispensers for field application. It is expected to be released into the atmosphere and degrade over time. The compound is soluble in organic solvents and is used as an analytical standard. It should be stored as a pure form at -20°C for up to 3 years or in solvent at -80°C for up to 6 months. It is stable at room temperature for short periods during shipping.
|
| Toxicity/Toxicokinetics |
Toxicity Summary
It is safe at the current usage and concentration. Ingredient, concentration, and usage information can be found at: https://cir-reports.cir-safety.org Tetradecyl acetate has been shown to have genotoxic activity, which may be due to its ability to inhibit transcriptional regulation. It is not toxic to mammals because it is quickly metabolized in the liver. Standard laboratory safety practices should be followed when handling this compound. The compound is primarily used in research and pest management applications. |
| References |
|
| Additional Infomation |
Tetradecyl acetate is a carboxylic acid ester. It has been reported to be found in Gnaphalium affine, Angelica sinensis, and other organisms with relevant data.
Tetradecyl acetate is a sex pheromone produced by female Ctenopseustis obliquana that can be used to disrupt the mating of pest species. It is used in pheromone research, analytical chemistry, and pest mating disruption studies. As an analytical standard, it is suitable for GC/MS analysis. The compound's role in insect chemical communication makes it valuable for studying insect behavior and developing environmentally friendly pest control strategies. It is for research use only. |
| Molecular Formula |
C16H32O2
|
|---|---|
| Molecular Weight |
256.42
|
| Exact Mass |
256.24
|
| CAS # |
638-59-5
|
| PubChem CID |
12531
|
| Appearance |
Colorless to off-white <14°C powder,>14°C liquid
|
| Density |
0.865g/cm3
|
| Boiling Point |
300.1ºC at 760 mmHg
|
| Flash Point |
133.6ºC
|
| Index of Refraction |
1.439
|
| LogP |
5.25
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
14
|
| Heavy Atom Count |
18
|
| Complexity |
178
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O(C(C([H])([H])[H])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
|
| InChi Key |
IOUUIFSIQMVYKP-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C16H32O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-18-16(2)17/h3-15H2,1-2H3
|
| Chemical Name |
tetradecyl acetate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (389.99 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.75 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.75 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.75 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.8999 mL | 19.4993 mL | 38.9985 mL | |
| 5 mM | 0.7800 mL | 3.8999 mL | 7.7997 mL | |
| 10 mM | 0.3900 mL | 1.9499 mL | 3.8999 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
