| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Tobacco mosaic virus (TMV). Methyl 4-hydroxyphenylacetate has potent inhibitory activity against tobacco mosaic virus (TMV). The compound's mechanism of antiviral action is not fully characterized but may involve interference with viral replication or assembly.
|
|---|---|
| ln Vitro |
Methyl 4-hydroxyphenylacetate has potent inhibitory activity against tobacco mosaic virus (TMV). The compound's antiviral activity has been demonstrated in plant-based assays. Its specific in vitro activities depend on the concentrations tested and the assay systems used.
|
| ln Vivo |
In vivo studies of methyl 4-hydroxyphenylacetate are limited to plant-based antiviral assays against TMV. The compound's efficacy against TMV infection in plants has been demonstrated. Further studies are needed to characterize its activity in other systems.
|
| Enzyme Assay |
Non-cell-based assays for methyl 4-hydroxyphenylacetate include antiviral activity assessment against TMV using standard plant virus inhibition assays. Standard analytical methods including HPLC, NMR, and mass spectrometry are used for compound characterization and purity assessment. Physicochemical properties such as melting point and boiling point are determined using standard protocols.
|
| Cell Assay |
Cell-based assays for methyl 4-hydroxyphenylacetate are primarily plant-based assays for antiviral activity against TMV. The compound's effects on viral replication and plant cell viability are assessed.
|
| Animal Protocol |
In vivo studies of methyl 4-hydroxyphenylacetate are conducted in plant models for antiviral evaluation against TMV. The compound is applied to plants, and viral infection and symptom development are monitored.
|
| ADME/Pharmacokinetics |
Methyl 4-hydroxyphenylacetate has a molecular formula of C₉H₁₀O₃ and a molecular weight of approximately 166.17 g/mol. It has a melting point of 55-58°C and a boiling point of 162-163°C at 5 mm Hg. The compound should be stored under inert gas and protected from moisture. It is a natural compound isolated from Fusarium oxysporum.
|
| Toxicity/Toxicokinetics |
Specific toxicity data for methyl 4-hydroxyphenylacetate are limited. Standard laboratory safety practices should be followed when handling this compound, including the use of personal protective equipment.
|
| References | |
| Additional Infomation |
Methyl 2-(4-hydroxyphenyl)acetate is a methyl ester formed by the condensation of the carboxyl group of 4-hydroxyphenylacetic acid with methanol. It has been isolated from Penicillium chrysogenum, a metabolite of this fungus. It belongs to the phenolic class of compounds and is a methyl ester. Its function is related to 4-hydroxyphenylacetic acid. Methyl 2-hydroxyphenylacetate has also been reported in Guanomyces polythrix, Penicillium herquei, and other organisms with relevant data.
Methyl 4-hydroxyphenylacetate is a methyl ester derived from 4-hydroxyphenylacetic acid. It is a natural compound isolated from Fusarium oxysporum and has potent inhibitory activity against tobacco mosaic virus (TMV). It is for research use only. |
| Molecular Formula |
C9H10O3
|
|---|---|
| Molecular Weight |
166.17
|
| Exact Mass |
170.964
|
| CAS # |
14199-15-6
|
| PubChem CID |
518900
|
| Appearance |
White to off-white solid
|
| Density |
1.4±0.1 g/cm3
|
| Boiling Point |
279.2±20.0 °C at 760 mmHg
|
| Melting Point |
55-58 °C(lit.)
|
| Flash Point |
126.8±16.0 °C
|
| Vapour Pressure |
0.0±0.6 mmHg at 25°C
|
| Index of Refraction |
1.584
|
| LogP |
2.79
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
12
|
| Complexity |
148
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O(C([H])([H])[H])C(C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])O[H])=O
|
| InChi Key |
XGDZEDRBLVIUMX-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C9H10O3/c1-12-9(11)6-7-2-4-8(10)5-3-7/h2-5,10H,6H2,1H3
|
| Chemical Name |
methyl 2-(4-hydroxyphenyl)acetate
|
| Synonyms |
Methyl 4-hydroxyphenylacetate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (601.79 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (15.04 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (15.04 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (15.04 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.0179 mL | 30.0897 mL | 60.1793 mL | |
| 5 mM | 1.2036 mL | 6.0179 mL | 12.0359 mL | |
| 10 mM | 0.6018 mL | 3.0090 mL | 6.0179 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
