| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
For topical use only (ophthalmic use). For topical use only (ophthalmic use). For topical use only (ophthalmic use). For topical use only (ophthalmic use). Metabolites/Metabolic Substances For topical use only (ophthalmic use). 4-Hydroxyamphetamine is a known metabolite of amphetamine in the human body. |
|---|---|
| Toxicity/Toxicokinetics |
Protein Binding
For topical use only (ophthalmic use). |
| References |
[1]. Mansoor Mughal, et al. Current pharmacologic testing for Horner syndrome. Curr Neurol Neurosci Rep. 2009 Sep;9(5):384-9.
|
| Additional Infomation |
4-(2-aminopropyl)phenol belongs to the amphetamine class of drugs. Hydroxypropylamine is a derivative of amphetamine. Hydroxypropylamine is primarily used as topical eye drops for diagnostic purposes. It is an indirect sympathomimetic drug that can cause pupillary dilation before diagnostic tests. Its minor side effects include: altered color vision, night blindness, dry mouth, headache, increased sensitivity of the eyes to sunlight, muscle stiffness or tightness, and temporary eye irritation. The main use of hydroxypropylamine as eye drops is for diagnosing Horner's syndrome, a syndrome characterized by nerve damage. Hydroxypropylamine is an adrenergic receptor agonist. Its mechanism of action is as an adrenergic agonist. 4-(2-aminopropyl)phenol has been reported in Senegalia berlandieri, and relevant data are available. Hydroxypropylamine is an indirect-acting sympathomimetic amine with adrenergic properties. When amphetamine is applied topically to the eye, it stimulates postganglionic adrenergic nerves to release norepinephrine, thereby stimulating α and β adrenergic receptors. Local α-receptor stimulation includes pupillary dilation, increased aqueous humor flow, and vasoconstriction; while β-receptor stimulation includes ciliary muscle relaxation and decreased aqueous humor production. Amphetamine metabolites have sympathomimetic effects. It is sometimes referred to as α-methyltyramine, and may also refer to the meta-isomer jeopardine. Drug Indications Used as a mydriatic (pupil dilator) for the diagnosis of ocular neuropathy. Mechanism of Action Amphetamine hydrobromide is an indirect-acting sympathomimetic drug that induces the release of norepinephrine from adrenergic nerve endings, leading to pupillary dilation.
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| Molecular Formula |
C9H13NO
|
|---|---|
| Molecular Weight |
151.21
|
| Exact Mass |
151.1
|
| CAS # |
103-86-6
|
| Related CAS # |
Hydroxyamphetamine hydrobromide;306-21-8;Hydroxyamphetamine hydrochloride;876-26-6
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| PubChem CID |
3651
|
| Appearance |
Typically exists as solid at room temperature
|
| Density |
1.07g/cm3
|
| Boiling Point |
279.2ºC at 760mmHg
|
| Flash Point |
122.7ºC
|
| LogP |
1.982
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
11
|
| Complexity |
108
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC(CC1=CC=C(C=C1)O)N
|
| InChi Key |
GIKNHHRFLCDOEU-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3
|
| Chemical Name |
4-(2-aminopropyl)phenol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (661.33 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.53 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.53 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.53 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.6133 mL | 33.0666 mL | 66.1332 mL | |
| 5 mM | 1.3227 mL | 6.6133 mL | 13.2266 mL | |
| 10 mM | 0.6613 mL | 3.3067 mL | 6.6133 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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