| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Not applicable (chemical intermediate). Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside is a chemical intermediate used in organic synthesis. It does not have a defined pharmacological target. The compound is used as a protected form of ribofuranose for the synthesis of nucleoside analogs and other bioactive compounds. Its biological effects, if any, would be related to the compounds synthesized from it rather than the reagent itself.
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|---|---|
| ln Vitro |
Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside is a chemical intermediate used in organic synthesis and does not exhibit direct pharmacological activity in standard in vitro assays. It is used to synthesize nucleoside analogs, arsenic-containing nucleoside compounds, and other carbohydrate-based bioactive molecules.
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| ln Vivo |
In vivo studies of methyl 2,3-O-isopropylidene-β-D-ribofuranoside are not applicable as the compound is a chemical intermediate rather than a pharmacologically active compound. It is used in organic synthesis to produce bioactive compounds that may be evaluated in vivo. The compound itself is not administered to animals for therapeutic or pharmacological studies.
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| Enzyme Assay |
Non-cell-based assays for methyl 2,3-O-isopropylidene-β-D-ribofuranoside are primarily analytical in nature. Standard methods including HPLC, NMR, and mass spectrometry are used for identification, quantification, and purity assessment. Physicochemical properties such as molecular weight (204.22 g/mol) and molecular formula (C₉H₁₆O₅) are determined using standard protocols. The compound is used as a reactant in organic synthesis reactions.
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| Cell Assay |
Cell-based assays for methyl 2,3-O-isopropylidene-β-D-ribofuranoside are not commonly performed, as the compound is a chemical intermediate rather than a pharmacologically active compound. Nucleoside analogs synthesized using this reagent may be tested in cell-based assays, but the reagent itself is not typically used in cell culture applications.
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| Animal Protocol |
In vivo animal studies for methyl 2,3-O-isopropylidene-β-D-ribofuranoside are not applicable as the compound is a chemical intermediate rather than a pharmacologically active compound. It is used in organic synthesis to produce compounds that may be evaluated in animal models.
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| ADME/Pharmacokinetics |
Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside has a molecular formula of C₉H₁₆O₅ and a molecular weight of 204.22 g/mol. The CAS number is 4099-85-8. It is developed from D-ribose and serves as an intermediate in the synthesis of arsenic-containing nucleoside compounds. The compound is a protected form of ribofuranose and should be stored under recommended conditions. It is intended for research use only.
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| Toxicity/Toxicokinetics |
Specific toxicity data for methyl 2,3-O-isopropylidene-β-D-ribofuranoside are limited. As a chemical intermediate, it may cause irritation to the skin, eyes, and respiratory tract. Standard laboratory safety practices should be followed when handling this compound.
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| References | |
| Additional Infomation |
Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside is a protected ribose derivative developed from D-ribose. It serves as an intermediate in the preparation and synthesis of arsenic-containing nucleoside compounds and other carbohydrate-based bioactive molecules. The isopropylidene group protects the 2,3-diol positions of the ribofuranose ring. It is a useful compound in organic synthesis and is intended for research use only.
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| Molecular Formula |
C9H16O5
|
|---|---|
| Molecular Weight |
204.22
|
| Exact Mass |
204.099
|
| CAS # |
4099-85-8
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| PubChem CID |
96666
|
| Appearance |
Colorless to light yellow liquid
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
287.3±40.0 °C at 760 mmHg
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| Flash Point |
127.5±27.3 °C
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| Vapour Pressure |
0.0±1.3 mmHg at 25°C
|
| Index of Refraction |
1.492
|
| LogP |
0.55
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
14
|
| Complexity |
217
|
| Defined Atom Stereocenter Count |
4
|
| SMILES |
O1C(C([H])([H])[H])(C([H])([H])[H])O[C@@]2([H])[C@]([H])(OC([H])([H])[H])O[C@]([H])(C([H])([H])O[H])[C@@]12[H]
|
| InChi Key |
DXBHDBLZPXQALN-WCTZXXKLSA-N
|
| InChi Code |
InChI=1S/C9H16O5/c1-9(2)13-6-5(4-10)12-8(11-3)7(6)14-9/h5-8,10H,4H2,1-3H3/t5-,6-,7-,8-/m1/s1
|
| Chemical Name |
[(3aR,4R,6R,6aR)-4-methoxy-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (489.67 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.24 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (12.24 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (12.24 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8967 mL | 24.4834 mL | 48.9668 mL | |
| 5 mM | 0.9793 mL | 4.8967 mL | 9.7934 mL | |
| 10 mM | 0.4897 mL | 2.4483 mL | 4.8967 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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