| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
| ln Vitro |
A wide variety of mammary cell line members are inhibited by PG-11047 (13 nM–5 mM; 72 h); basal-like cell lines are inhibited at lower dosages than luminal cell lines [1]. S phase fraction was significantly reduced by PG-11047 (0.3, 10, 300 μM; 48 h, 72 h) at levels that virtually completely prevented apoptosis [1].
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|---|---|
| Cell Assay |
Cell Cycle Analysis[1]
Cell Types: Breast cancer cell lines Tested Tested Concentrations: 0.3, 10, 300 μM Incubation Duration: 48 h, 72 h Experimental Results: Significant diminished the fraction of cells in S-phase with increasing doses. Apoptosis Analysis[1] Cell Types: Breast cancer cell lines Tested Tested Concentrations: 0.3, 10, 300 μM Incubation Duration: 48 h, 72 h Experimental Results: Induced apoptosis at high concentrations. |
| References |
[1]. Wen-Lin Kuo, et al. A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047. BMC Med. 2009 Dec 14;7:77.
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| Molecular Formula |
C14H32N4
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|---|---|
| Molecular Weight |
256.430683135986
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| Exact Mass |
256.262
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| CAS # |
308145-19-9
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| Related CAS # |
PG-11047 tetrahydrochloride;206991-64-2
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| PubChem CID |
6475492
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| Appearance |
Light yellow to yellow oil
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| LogP |
0.3
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
14
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| Heavy Atom Count |
18
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| Complexity |
153
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCNCCCNC/C=C\CNCCCNCC
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| InChi Key |
XFWLTFZLLXVKDY-WAYWQWQTSA-N
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| InChi Code |
InChI=1S/C14H32N4/c1-3-15-11-7-13-17-9-5-6-10-18-14-8-12-16-4-2/h5-6,15-18H,3-4,7-14H2,1-2H3/b6-5-
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| Chemical Name |
(Z)-N,N'-bis[3-(ethylamino)propyl]but-2-ene-1,4-diamine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~390.0 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (9.75 mM) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution; with ultrasonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (9.75 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: 2.5 mg/mL (9.75 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.8997 mL | 19.4985 mL | 38.9970 mL | |
| 5 mM | 0.7799 mL | 3.8997 mL | 7.7994 mL | |
| 10 mM | 0.3900 mL | 1.9498 mL | 3.8997 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Link: https://clinicaltrials.gov/ct2/show/NCT00705653
Conditions:CancerProducts are for research use only; We do not sell to patients
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