| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
Respiratory tract (gastric-reflex expectorant). Guaiacol Carbonate functions as a gastric-reflex expectorant. As a prodrug of guaiacol, it is hydrolytically stable, ensuring intact prodrug transit to enable targeted gastric-reflex action. Its mechanism involves stimulation of gastric reflexes that promote respiratory tract secretion and expectoration.
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|---|---|
| ln Vitro |
Guaiacol Carbonate is a gastric-reflex expectorant. As a prodrug of guaiacol, it exhibits hydrolytic stability, ensuring intact prodrug transit and enabling targeted gastric-reflex action. Its near-complete water insolubility and high melting point (86-90°C) permit direct compression tableting and sustained-release matrices.
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| ln Vivo |
In vivo, guaiacol carbonate functions as a gastric-reflex expectorant. As a prodrug of guaiacol, it is hydrolytically stable, ensuring intact prodrug transit and enabling targeted gastric-reflex action. It is used in pharmaceutical formulations for its expectorant properties. Conventional guaiacol derivatives pose solubility and stability challenges for gastric-reflex expectorant formulations, which guaiacol carbonate resolves.
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| Enzyme Assay |
Non-cell-based assays for guaiacol carbonate include characterization of its physicochemical properties. Standard methods including HPLC, NMR, and mass spectrometry are used for identification, quantification, and purity assessment. Melting point (86-90°C) and solubility in organic solvents are determined using standard protocols. Hydrolytic stability is assessed under various pH conditions.
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| Cell Assay |
Cell-based assays for guaiacol carbonate are not commonly performed, as the compound is primarily used as an expectorant prodrug and industrial chemical. Its mechanism of action is mediated through gastric reflexes rather than direct cellular effects.
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| Animal Protocol |
In vivo studies of guaiacol carbonate are conducted in animal models to assess its expectorant activity. The compound is administered orally, and its effects on respiratory tract secretion and mucus clearance are assessed. Pharmacokinetic studies evaluate its absorption, distribution, metabolism, and excretion. The compound's hydrolytic stability ensures intact prodrug transit.
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| ADME/Pharmacokinetics |
Guaiacol Carbonate has a molecular formula of C₁₅H₁₄O₅ and a molecular weight of 274.27 g/mol. It is a white to almost white crystalline powder with a melting point of 86-90°C. Purity is ≥98%. It is practically insoluble in water but soluble in organic solvents like methanol, ethanol, chloroform, and ether. Storage: sealed in dry, room temperature.
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| Toxicity/Toxicokinetics |
Guaiacol Carbonate is a guaiacol derivative that functions as a gastric-reflex expectorant in pharmaceutical applications. It is generally considered to have low toxicity. Standard laboratory safety practices should be followed when handling this compound.
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| References |
[1]. Stevens ME, et al. On the Expectorant Action of Creosote and the Guaiacols. Can Med Assoc J. 1943;48(2):124-127.
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| Additional Infomation |
Guaiacol carbonate belongs to the methoxybenzene class of compounds.
Guaiacol Carbonate (Bis(2-methoxyphenyl) carbonate, Duotal) is a neutral diester of carbonic acid and guaiacol. It functions as a gastric-reflex expectorant in pharmaceutical applications and also serves as a polymer stabilizer and plasticizer in industrial contexts. It is hydrolytically stable, ensuring intact prodrug transit. It is for research use only. |
| Molecular Formula |
C15H14O5
|
|---|---|
| Molecular Weight |
274.27
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| Exact Mass |
274.084
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| CAS # |
553-17-3
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| PubChem CID |
11104
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
392.6±27.0 °C at 760 mmHg
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| Melting Point |
88°C
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| Flash Point |
173.7±23.8 °C
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| Vapour Pressure |
0.0±0.9 mmHg at 25°C
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| Index of Refraction |
1.552
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| LogP |
2.41
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
6
|
| Heavy Atom Count |
20
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| Complexity |
279
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| Defined Atom Stereocenter Count |
0
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| SMILES |
COC1=CC=CC=C1OC(=O)OC2=CC=CC=C2OC
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| InChi Key |
ORUJFMPWKPVXLZ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H14O5/c1-17-11-7-3-5-9-13(11)19-15(16)20-14-10-6-4-8-12(14)18-2/h3-10H,1-2H3
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| Chemical Name |
bis(2-methoxyphenyl) carbonate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (364.60 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.12 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.12 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6460 mL | 18.2302 mL | 36.4604 mL | |
| 5 mM | 0.7292 mL | 3.6460 mL | 7.2921 mL | |
| 10 mM | 0.3646 mL | 1.8230 mL | 3.6460 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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