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| Other Sizes |
| Targets |
10-Undecen-1-ol does not have a specific, well-established biological or pharmacological target. Its value lies in its chemical reactivity as a building block. In biological research, its derivatives and related compounds, such as 10-undecenoic acid, have shown promise, including antifungal activity through the disruption of fungal cell membranes. In silico studies have suggested that some related volatile phytochemicals could potentially act as aromatase inhibitors.
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| ln Vitro |
Step growth polymerization of undec-10-en-1-ol and CO catalyzed by cobalt results in aliphatic polyesters (Mn 104 g/mol) that are only derived from renewable resources[1].
In vitro, the compound itself is not typically studied for direct biological activity. However, its derivatives have shown promise. For instance, 10-undecenoic acid, a closely related compound, is a known antifungal agent. Research suggests that 10-Undecen-1-ol has the potential to modulate specific cellular signaling pathways by influencing the activity of certain enzymes, positioning it as a molecule of interest in fundamental research areas like cancer and inflammation. |
| ln Vivo |
In vivo, 10-Undecen-1-ol is not administered as a therapeutic agent. Its primary applications are in industrial chemistry and as a precursor for synthesizing other compounds. While some of its derivatives may have biological applications, the parent compound itself is not used for in vivo pharmacological studies. It is considered safe for its intended uses, such as a flavoring agent in food.
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| Enzyme Assay |
Non-cell-based assays for 10-Undecen-1-ol primarily involve characterizing its chemical properties and reactivity. These methods include Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) for structural confirmation, and Gas Chromatography (GC) to assess purity. Its role as a monomer is evaluated in polymerization reactions, such as Acyclic Diene Metathesis (ADMET) and copolymerization with ethylene, where its incorporation rate into polymer chains is measured.
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| Cell Assay |
10-Undecen-1-ol is not typically used in standard cell-based assays as it is not considered a primary bioactive compound. Its role in cellular research is indirect, serving as a building block to create other molecules that might be tested in such assays. While some commercial sources suggest it can modulate cellular signaling pathways, specific experimental protocols for cell-based assays using the compound itself are not established.
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| Animal Protocol |
10-Undecen-1-ol is not used as a therapeutic agent in animal experiments. Its primary applications are in industrial chemistry and as a precursor for synthesizing other compounds. While some of its derivatives may have biological applications, the parent compound itself is not used for in vivo pharmacological studies.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties are not applicable to 10-Undecen-1-ol in a therapeutic context. As a chemical intermediate and flavoring agent, its absorption, distribution, metabolism, and excretion (ADME) are not characterized as they would be for a drug. Its physical properties, such as being insoluble in water but soluble in alcohol, are relevant for its use in industrial and flavor applications.
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| Toxicity/Toxicokinetics |
The toxicity of 10-Undecen-1-ol has been evaluated primarily for its use as a flavoring agent and industrial chemical. It is reported to be a mild skin irritant and a strong eye irritant. However, it is considered safe for use as a flavoring agent in food. Standard laboratory safety precautions should be followed when handling the compound to avoid exposure.
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| References |
[1]. Quinzler D, et al. Renewable resource-based poly(dodecyloate) by carbonylation polymerization. Chem Commun (Camb). 2009;(36):5400-5402.
[2]. Jonas U. A, et al. Functional Beads of Polyvinylpyrrolidone: Promising Support Materials for Solid‐Phase Synthesis. |
| Additional Infomation |
10-Undecen-1-ol is an enol formed by replacing a terminal methyl hydrogen atom in the 1-undecene molecule with a hydroxyl group. It is an enol, primary alcohol, and medium-chain fatty alcohol. It is derived from the hydride of 1-undecene.
It has been reported that 10-undecen-1-ol is present in mango (Mangifera indica), and relevant data are available for reference. 10-Undecen-1-ol (CAS# 112-43-6) is a colorless liquid with the molecular formula C₁₁H₂₂O and a molecular weight of 170.29 g/mol. Also known as undec-10-en-1-ol or undecylenyl alcohol, it is a primary alcohol and a medium-chain fatty alcohol. It is synthesized primarily through the reduction of 10-undecenoic acid. Its main applications are as a chemical intermediate for synthesizing polymers, specialty chemicals, and insect pheromones, and as a flavor and fragrance ingredient. It is not approved as a therapeutic agent. |
| Molecular Formula |
C11H22O
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|---|---|
| Molecular Weight |
170.29
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| Exact Mass |
170.167
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| CAS # |
112-43-6
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| PubChem CID |
8185
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| Appearance |
Colorless to light yellow liquid（Density：0.85 g/cm3 ）
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| Density |
0.8±0.1 g/cm3
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| Boiling Point |
250.0±0.0 °C at 760 mmHg
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| Melting Point |
-2 °C
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| Flash Point |
93.3±0.0 °C
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| Vapour Pressure |
0.0±1.1 mmHg at 25°C
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| Index of Refraction |
1.448
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| LogP |
4.09
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
9
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| Heavy Atom Count |
12
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| Complexity |
89
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])=C([H])[H]
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| InChi Key |
GIEMHYCMBGELGY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H22O/c1-2-3-4-5-6-7-8-9-10-11-12/h2,12H,1,3-11H2
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| Chemical Name |
undec-10-en-1-ol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (587.23 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (14.68 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (14.68 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (14.68 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.8723 mL | 29.3617 mL | 58.7234 mL | |
| 5 mM | 1.1745 mL | 5.8723 mL | 11.7447 mL | |
| 10 mM | 0.5872 mL | 2.9362 mL | 5.8723 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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