| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Pentacosane does not have a specific biological target.
|
|---|---|
| ln Vitro |
Pentacosane demonstrates antitumor activity against A549 (lung cancer), THP-1 (acute monocytic leukemia), CHOK1 (ovarian), and C-6 cells[1].
Pentacosane demonstrates antitumor activity against A549 (lung cancer), THP-1 (acute monocytic leukemia), CHOK1 (ovarian), and C-6 cells. It also shows strong activity against bacterial strains, including methicillin-resistant Staphylococcus aureus, by disrupting hydrogen bonds on the cell surface and blocking the synthesis of fatty acids. |
| ln Vivo |
In vivo activity data for Pentacosane are not available.
|
| Enzyme Assay |
Non-cell-based assays for Pentacosane are not described.
|
| Cell Assay |
Cancer cell lines such as A549, THP-1, CHOK1, and C-6 cells are treated with Pentacosane at various concentrations. Cell viability is measured using a suitable assay such as MTT or CCK-8. The antitumor activity is determined from the dose-response curves.
|
| Animal Protocol |
In vivo animal studies are not applicable.
|
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Samples were collected from the liver, heart, kidneys, muscle, and adipose tissue (perirhinal and subcutaneous) of six cattle for hydrocarbon composition analysis. Qualitative and quantitative analyses were performed using gas chromatography and gas chromatography-mass spectrometry. Despite varying proportions, a series of homologous n-alkanes with carbon chain lengths ranging from n-C12 to n-C31 were found in all samples. Additionally, isoprene hydrocarbons phytane and phyene (phytane-1 and phyene-2) were identified. (These findings are highly relevant to human health from consuming hydrocarbon-contaminated meat.) /n-Alkanes/ Pharmacokinetic data for Pentacosane are not available. |
| Toxicity/Toxicokinetics |
Toxicity Summary
Identification and Uses: Pentacosane is a solid n-alkane containing 25 carbon atoms (C25). Solid n-alkanes (paraffin) have a wide range of uses: they can be used as feedstock in gasoline blending and in oxidation and chlorination reactions. Human Exposure and Toxicity: No relevant data are currently available. Animal Studies: A series of homologues of n-alkanes with n-C12 to n-C31 carbon atoms were found in all bovine tissue samples. Toxicological data for Pentacosane are not available. |
| References | |
| Additional Infomation |
Composition of various natural waxes. A colorless solid at room temperature and pressure.
Petrodecane is an unbranched alkane composed of 25 carbon atoms. It is a pheromone and a plant metabolite. Petrodecane has been reported to exist in Euphorbia piscatoria, Vanilla madagascariensis, and other organisms with relevant data. See also: Moringa leaf oil (partial). Pentacosane is an aliphatic hydrocarbon found in various essential oils. It has antitumor activity. |
| Molecular Formula |
C25H52
|
|---|---|
| Molecular Weight |
352.68
|
| Exact Mass |
352.406
|
| CAS # |
629-99-2
|
| Related CAS # |
Pentacosane-d52; 121578-13-0
|
| PubChem CID |
12406
|
| Appearance |
White to off-white solid
|
| Density |
0.8±0.1 g/cm3
|
| Boiling Point |
401.9±8.0 °C at 760 mmHg
|
| Melting Point |
53.3 °C
|
| Flash Point |
246.1±8.0 °C
|
| Vapour Pressure |
0.0±0.4 mmHg at 25°C
|
| Index of Refraction |
1.447
|
| LogP |
14.04
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
0
|
| Rotatable Bond Count |
22
|
| Heavy Atom Count |
25
|
| Complexity |
186
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C([H])([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
|
| InChi Key |
YKNWIILGEFFOPE-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C25H52/c1-3-5-7-9-11-13-15-17-19-21-23-25-24-22-20-18-16-14-12-10-8-6-4-2/h3-25H2,1-2H3
|
| Chemical Name |
pentacosane
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 5 mg/mL (14.18 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.5 mg/mL (1.42 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.5 mg/mL (1.42 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 0.5 mg/mL (1.42 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8354 mL | 14.1772 mL | 28.3543 mL | |
| 5 mM | 0.5671 mL | 2.8354 mL | 5.6709 mL | |
| 10 mM | 0.2835 mL | 1.4177 mL | 2.8354 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
