| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
This compound does not have biological targets. It is used as an internal standard or tracer in analytical chemistry.
|
|---|---|
| ln Vitro |
Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
Not applicable. The compound is an isotopically labeled reagent. |
| ln Vivo |
Not applicable.
|
| Enzyme Assay |
Not applicable.
|
| Cell Assay |
Not applicable.
|
| Animal Protocol |
Not applicable.
|
| ADME/Pharmacokinetics |
The compound is a stable isotope-labeled reagent used as a reference standard. It is stable under recommended storage conditions.
|
| Toxicity/Toxicokinetics |
The compound is handled with standard laboratory precautions.
|
| References | |
| Additional Infomation |
2-Chloro-2-methylpropane-d9 is a research-use-only stable isotope-labeled compound. It is used in organic synthesis and as a reference standard in analytical workflows.
|
| Molecular Formula |
C4D9CL
|
|---|---|
| Molecular Weight |
92.56726
|
| Exact Mass |
101.096
|
| CAS # |
918-20-7
|
| PubChem CID |
13517
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
0.933 g/mL at 25ºC
|
| Boiling Point |
51-52ºC(lit.)
|
| Melting Point |
-25ºC(lit.)
|
| Flash Point |
65 °F
|
| Index of Refraction |
n20/D 1.3819(lit.)
|
| LogP |
2.023
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
0
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
5
|
| Complexity |
25.1
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC(C)(C)Cl
|
| InChi Key |
NBRKLOOSMBRFMH-GQALSZNTSA-N
|
| InChi Code |
InChI=1S/C4H9Cl/c1-4(2,3)5/h1-3H3/i1D3,2D3,3D3
|
| Chemical Name |
2-chloro-1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propane
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~984.1 mM; with ultrasonication)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (24.60 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (24.60 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (24.60 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 10.8026 mL | 54.0132 mL | 108.0264 mL | |
| 5 mM | 2.1605 mL | 10.8026 mL | 21.6053 mL | |
| 10 mM | 1.0803 mL | 5.4013 mL | 10.8026 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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