| Size | Price | |
|---|---|---|
| Other Sizes |
Purity: N/A
| Targets |
Biochemical Assay Reagent
Pd(Xantphos)Cl2 is a catalyst for cross-coupling reactions such as carbonylation, amination, and other C-C and C-N bond-forming reactions. It does not have biological targets. |
|---|---|
| ln Vitro |
The catalyst enables various organic transformations, including the carbonylation of toluene derivatives with amines. Its activity is measured by reaction yield and selectivity.
|
| ln Vivo |
Not applicable. This compound is a chemical reagent, not a drug.
|
| Enzyme Assay |
Catalytic activity is assessed by monitoring reaction progress using GC, HPLC, or NMR spectroscopy. Substrate conversion and product yield are calculated.
|
| Cell Assay |
Not applicable. Cell-based assays are not relevant for this catalyst.
|
| Animal Protocol |
Not applicable.
|
| ADME/Pharmacokinetics |
Not applicable.
|
| Toxicity/Toxicokinetics |
The compound is a catalyst and is handled with standard laboratory precautions for palladium complexes.
|
| Additional Infomation |
Pd(Xantphos)Cl2 is a research-use-only chemical reagent. It is widely used in organic synthesis for cross-coupling reactions. It is not a pharmaceutical compound.
|
| Molecular Formula |
C39H32CL2OP2PD
|
|---|---|
| Molecular Weight |
755.94438
|
| Exact Mass |
754.033
|
| CAS # |
205319-10-4
|
| PubChem CID |
60153068
|
| Appearance |
White to yellow solid powder
|
| Melting Point |
287 °C(dec.)
|
| LogP |
1.642
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
6
|
| Heavy Atom Count |
45
|
| Complexity |
734
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC1(C)C2=C(C([P+]3(C4=CC=CC=C4)C5=CC=CC=C5)=CC=C2)OC6=C([P+](C7=CC=CC=C7)([Pd-2]3(Cl)Cl)C8=CC=CC=C8)C=CC=C61
|
| InChi Key |
HEYONDYPXIUDCK-UHFFFAOYSA-L
|
| InChi Code |
InChI=1S/C39H32OP2.2ClH.Pd/c1-39(2)33-25-15-27-35(41(29-17-7-3-8-18-29)30-19-9-4-10-20-30)37(33)40-38-34(39)26-16-28-36(38)42(31-21-11-5-12-22-31)32-23-13-6-14-24-32;;;/h3-28H,1-2H3;2*1H;/q;;;+2/p-2
|
| Chemical Name |
dichloropalladium;(5-diphenylphosphanyl-9,9-dimethylxanthen-4-yl)-diphenylphosphane
|
| Synonyms |
205319-10-4; Dichloro-(4,5-bis(diphenylphosphino)-9,9-dimethylxanthene)palladium(II); 685-312-0; DICHLORO[9,9-DIMETHYL-4,5-BIS(DIPHENYLPHOSPHINO)XANTHENE]PALLADIUM(II); MFCD14155707; dichloropalladium;(5-diphenylphosphanyl-9,9-dimethylxanthen-4-yl)-diphenylphosphane; PdCl2(Xant-Phos); Dichloro[9,9-dimethyl-4,5- bis(diphenylphosphino)xanthene]palladium(II)
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: ~5.7 mg/mL (~7.6 mM; with ultrasonication and warming by heating to 60°C)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.57 mg/mL (0.75 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (5.7 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.3229 mL | 6.6143 mL | 13.2286 mL | |
| 5 mM | 0.2646 mL | 1.3229 mL | 2.6457 mL | |
| 10 mM | 0.1323 mL | 0.6614 mL | 1.3229 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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