| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg | |||
| Other Sizes |
| Targets |
No confirmed biological target; likely interacts with enzymes or receptors recognizing tryptophan/acetyl-tryptophan (e.g., tryptophan hydroxylase, indoleamine 2,3-dioxygenase).
|
|---|---|
| ln Vitro |
No reported activity; serves as a reference or negative control for N-Acetyl-L-tryptophan, potentially influencing steric/electronic properties for mechanistic studies.
|
| ln Vivo |
No reported activity; used as an inactive analog to study N-Acetyl-L-tryptophan's role in biological processes.
|
| Enzyme Assay |
Not applicable; no specific protocols exist; typical enzyme binding studies would involve incubating with target enzyme and measuring activity compared to N-Acetyl-L-tryptophan.
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| Cell Assay |
No standard protocol; would be used as a control compound in cell-based assays, possibly at concentrations similar to N-Acetyl-L-tryptophan (e.g., 1-100 microM).
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| Animal Protocol |
No standard protocol; used as a chemical tool in animal models to study N-Acetyl-L-tryptophan-related pathways, likely administered via IP or IV injection.
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| ADME/Pharmacokinetics |
No PK data available; modifications may alter absorption, distribution, metabolism, and excretion compared to N-Acetyl-L-tryptophan.
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| Toxicity/Toxicokinetics |
No toxicity data available; expected to be low, based on structural similarity to endogenous tryptophan metabolites.
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| Additional Infomation |
This research chemical is used to study tryptophan metabolism and signaling. It has no therapeutic applications and is strictly for laboratory research, not for clinical use.
|
| Molecular Formula |
C14H16N2O3
|
|---|---|
| Molecular Weight |
260.29
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| Exact Mass |
260.116
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| CAS # |
114872-77-4
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| PubChem CID |
3315196
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| Appearance |
White to light yellow solid powder
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| LogP |
1.4
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| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
19
|
| Complexity |
359
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC1=CC2=C(C=C1)NC=C2C[C@@H](C(=O)O)NC(=O)C
|
| InChi Key |
GTCLKZDZUKYDDV-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C14H16N2O3/c1-8-3-4-12-11(5-8)10(7-15-12)6-13(14(18)19)16-9(2)17/h3-5,7,13,15H,6H2,1-2H3,(H,16,17)(H,18,19)
|
| Chemical Name |
2-acetamido-3-(5-methyl-1H-indol-3-yl)propanoic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (384.19 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.60 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.60 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.60 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.8419 mL | 19.2093 mL | 38.4187 mL | |
| 5 mM | 0.7684 mL | 3.8419 mL | 7.6837 mL | |
| 10 mM | 0.3842 mL | 1.9209 mL | 3.8419 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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