| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
(S)-Boc-nipecotic acid does not have specific pharmacological targets, as it is a biochemical reagent used in organic synthesis rather than a therapeutic agent. The Boc (tert-butoxycarbonyl) group serves as a protecting group for the amine functionality during peptide synthesis. The compound is used as a building block in the synthesis of various bioactive molecules.
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|---|---|
| ln Vitro |
(S)-Boc-nipecotic acid is not evaluated for traditional biological activity, as it is a biochemical reagent used in organic synthesis rather than a pharmacologically active compound. Its utility is based on its chemical properties as a protected amino acid derivative. No specific in vitro activity data have been reported.
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| ln Vivo |
(S)-Boc-nipecotic acid is not used for in vivo pharmacological evaluation. It is a biochemical reagent used in laboratory research for organic synthesis. The compound is not administered to animals for therapeutic purposes. Its applications are limited to chemical synthesis and medicinal chemistry research.
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| Enzyme Assay |
(S)-Boc-nipecotic acid is not evaluated in traditional enzyme/receptor binding assays. The compound's purity and identity are confirmed by standard analytical methods including HPLC, NMR, and mass spectrometry. Purity is typically ≥95%. The compound is used as a building block in peptide synthesis and medicinal chemistry.
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| Cell Assay |
(S)-Boc-nipecotic acid is not evaluated in traditional cellular assays, as it is a biochemical reagent used in organic synthesis rather than a cellular modulator. The compound may be used in the synthesis of molecules that are subsequently tested in cellular assays. However, the compound itself is not tested in cellular systems.
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| Animal Protocol |
(S)-Boc-nipecotic acid is not used in in vivo animal experiments. It is a biochemical reagent used in laboratory research for organic synthesis. The compound is not administered to animals for pharmacological evaluation. Its applications are limited to chemical synthesis and medicinal chemistry research.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties are not applicable to (S)-Boc-nipecotic acid, as it is a biochemical reagent used in organic synthesis rather than a therapeutic agent. The compound has a molecular weight of 229.28 g/mol and a molecular formula of C₁₁H₁₉NO₄. Storage: powder at -20°C for 3 years; in solvent at -80°C for 6 months or -20°C for 1 month.
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| Toxicity/Toxicokinetics |
The toxicological profile of (S)-Boc-nipecotic acid has not been extensively documented, as it is a biochemical reagent used in research rather than a therapeutic agent. Standard laboratory safety precautions should be followed when handling this compound. The compound is not intended for human consumption.
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| References | |
| Additional Infomation |
(S)-Boc-nipecotic acid (CAS# 88495-54-9, molecular formula C₁₁H₁₉NO₄, molecular weight 229.28) is a biochemical reagent used in life science related research. Also known as (S)-1-Boc-piperidine-3-carboxylic acid. No clinical trials or regulatory approvals have been identified. Purity ≥99.76%.
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| Molecular Formula |
C11H19NO4
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|---|---|
| Molecular Weight |
229.27
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| Exact Mass |
229.131
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| CAS # |
88495-54-9
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| PubChem CID |
6951168
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| Appearance |
White to off-white solid powder
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| Density |
1.164 g/cm3
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| Boiling Point |
353.2ºC at 760 mmHg
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| Melting Point |
159-162ºC(lit.)
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| Flash Point |
167.4ºC
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| Index of Refraction |
1.496
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| LogP |
1.656
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
16
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| Complexity |
282
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C(N1CCC[C@H](C(=O)O)C1)(=O)OC(C)(C)C
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| InChi Key |
NXILIHONWRXHFA-QMMMGPOBSA-N
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| InChi Code |
InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-5-8(7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m0/s1
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| Chemical Name |
(3S)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-3-carboxylic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~436.2 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.90 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.90 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (10.90 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.3617 mL | 21.8083 mL | 43.6167 mL | |
| 5 mM | 0.8723 mL | 4.3617 mL | 8.7233 mL | |
| 10 mM | 0.4362 mL | 2.1808 mL | 4.3617 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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