| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Thioisonicotinamide does not have a specific biological target. As a thioamide, it may have antimicrobial or other activities, but specific targets are not well characterized. It is primarily a research chemical.
|
|---|---|
| ln Vitro |
In vitro, Thioisonicotinamide is a chemical compound used in research. Detailed in vitro activity data, including IC50 values, are not reported. It may be used as a building block in organic synthesis or in studies of thioamide chemistry.
|
| ln Vivo |
In vivo, Thioisonicotinamide is not used as a therapeutic agent. It is a research chemical. No specific pharmacological activities have been reported.
|
| Enzyme Assay |
Cell-free assays for Thioisonicotinamide are not typical. As a chemical compound, its characterization includes determination of purity by HPLC and structural confirmation by NMR and mass spectrometry. No specific biological assays are applicable.
|
| Cell Assay |
Cellular assays for Thioisonicotinamide are not typical. As a research chemical, it is not used in cellular bioactivity screening. No specific cellular effects have been reported.
|
| Animal Protocol |
In vivo animal studies for Thioisonicotinamide have not been reported. As a research chemical, it is not used in therapeutic animal studies. No specific pharmacological studies have been described.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties of Thioisonicotinamide are not extensively characterized. As a small molecule (MW 138.19), it may have moderate bioavailability. Storage: typically at -20°C.
|
| Toxicity/Toxicokinetics |
Comprehensive toxicity data for Thioisonicotinamide are limited. As a thioamide, it may have toxicity at high doses. It is for research use only and not approved for clinical use. Standard laboratory safety precautions should be followed.
|
| Additional Infomation |
Thioisonicotinamide is a research compound used as a chemical building block and in studies of thioamide chemistry. It is available from chemical suppliers. No clinical applications have been reported.
|
| Molecular Formula |
C6H6N2S
|
|---|---|
| Molecular Weight |
138.19
|
| Exact Mass |
138.025
|
| CAS # |
2196-13-6
|
| PubChem CID |
2723788
|
| Appearance |
Typically exists as solid at room temperature
|
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
278.9±32.0 °C at 760 mmHg
|
| Melting Point |
201 °C
|
| Flash Point |
122.5±25.1 °C
|
| Vapour Pressure |
0.0±0.6 mmHg at 25°C
|
| Index of Refraction |
1.664
|
| LogP |
0.23
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
9
|
| Complexity |
108
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
S=C(C1C([H])=C([H])N=C([H])C=1[H])N([H])[H]
|
| InChi Key |
KPIIGXWUNXGGCP-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C6H6N2S/c7-6(9)5-1-3-8-4-2-5/h1-4H,(H2,7,9)
|
| Chemical Name |
pyridine-4-carbothioamide
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (723.64 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (18.09 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.2364 mL | 36.1821 mL | 72.3641 mL | |
| 5 mM | 1.4473 mL | 7.2364 mL | 14.4728 mL | |
| 10 mM | 0.7236 mL | 3.6182 mL | 7.2364 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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