| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| Other Sizes |
| Targets |
Dihydropinosylvin exhibits antifungal and antibacterial activities. It shows antifungal activity against Cladosporium cladosporioides, Botryodiplodia theobromae, Aspergillus niger, and Penicillium schlerotgenum. It also exhibits strong antibacterial activity against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. It inhibits seed germination and root elongation.
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|---|---|
| ln Vitro |
In vitro, Dihydropinosylvin shows antifungal activity against multiple fungal strains. It exhibits strong antibacterial activity against various bacteria. It inhibits the germination of seeds and root elongation in young seedlings of Sorghum bicolor. It is a phytoalexin that is induced in response to fungal infection or chemical treatment.
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| ln Vivo |
In vivo, Dihydropinosylvin has potential applications as a natural antifungal and antibacterial agent. Its phytoalexin properties suggest a role in plant defense against pathogens. No specific therapeutic applications in animals have been reported.
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| Enzyme Assay |
Cell-free assays for Dihydropinosylvin involve antifungal and antibacterial activity testing. Antifungal activity is assessed by agar diffusion or broth microdilution assays against fungal strains. Antibacterial activity is assessed similarly against bacterial strains. The compound is incubated with microorganisms, and growth inhibition is measured. IC50 or MIC values are calculated.
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| Cell Assay |
Cellular assays for Dihydropinosylvin are not typical, as it is a phytoalexin studied primarily in plant systems. Plant cells or tissues are treated with the compound, and its effects on seed germination, root elongation, and pathogen defense are assessed.
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| Animal Protocol |
In vivo animal studies for Dihydropinosylvin have not been reported. As a plant phytoalexin, its primary applications are in agricultural and plant biology research. No therapeutic animal studies have been described.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Dihydropinosylvin are not extensively characterized. Molecular weight: 214.26. Solubility: DMSO (<2.14 mg/mL, slightly soluble). Storage: powder at -20°C for up to 3 years; in solvent at -80°C for 1 year. Purity: ≥98%.
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| Toxicity/Toxicokinetics |
Comprehensive toxicity data for Dihydropinosylvin are limited. As a natural phytoalexin, it is generally considered safe at moderate doses. It is for research use only and not approved for clinical use.
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| References | |
| Additional Infomation |
Dihydropinosylvin belongs to the resorcinol class of compounds, with an additional 2-phenylethyl substituent at the 5-position. It is an EC 1.14.18.1 (tyrosinase) inhibitor and a plant metabolite. It belongs to the resorcinol and diphenylethane classes. Dihydropinosylvin has been reported to exist in Pinus sylvestris, Stemona pierrei, and several other organisms with relevant data.
Dihydropinosylvin is a research compound with potential applications in antifungal, antibacterial, and agricultural research. It is a phytoalexin found in various plant species. Its mechanism involves antimicrobial activity. No clinical trials or FDA approvals have been reported. |
| Molecular Formula |
C14H14O2
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|---|---|
| Molecular Weight |
214.26
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| Exact Mass |
214.099
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| CAS # |
14531-52-3
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| PubChem CID |
442700
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| Appearance |
White to off-white solid
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
366.0±17.0 °C at 760 mmHg
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| Flash Point |
175.7±15.5 °C
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| Vapour Pressure |
0.0±0.9 mmHg at 25°C
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| Index of Refraction |
1.631
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| LogP |
3.24
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
16
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| Complexity |
189
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| Defined Atom Stereocenter Count |
0
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| SMILES |
OC1=CC(O)=CC(CCC2C=CC=CC=2)=C1
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| InChi Key |
LDBYHULIXFIJAZ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C14H14O2/c15-13-8-12(9-14(16)10-13)7-6-11-4-2-1-3-5-11/h1-5,8-10,15-16H,6-7H2
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| Chemical Name |
5-(2-phenylethyl)benzene-1,3-diol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (466.72 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (11.67 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (11.67 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (11.67 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6672 mL | 23.3361 mL | 46.6723 mL | |
| 5 mM | 0.9334 mL | 4.6672 mL | 9.3345 mL | |
| 10 mM | 0.4667 mL | 2.3336 mL | 4.6672 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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