| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| ln Vivo |
BMS-986458 can phenotypically regulate the lymphoid-resident Tfh cell population in immune-normal mice without reducing cell viability[1]. Single treatment with BMS-986458 (5 mg/kg; orally; twice daily) can reduce tumor volume and moderately increase CD3+ cell infiltration at the tumor margin; its combination with Glofitamab showed synergistic anti-tumor efficacy in humanized DLBCL mouse models and enhanced CD3+ cell tumor infiltration[3].
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| Animal Protocol |
Animal/Disease Models:hCRBN NSG mouse diffuse large B-cell lymphoma (DLBCL) model [3]
Doses: 5 mg/kg; combined with Glofitamab (1 μg/mouse, intravenous injection, once a week) Route of Administration: Oral; twice daily Experimental Results: Compared with the vector group, the tumor volume was reduced by 59%; after 2 weeks of treatment, the CD3⁺ cells at the tumor margin increased slightly; when used in combination with glofitamab, the tumor volume was reduced by 97%, and the tumors of 6 out of 8 mice disappeared completely. Compared with other groups, the CD3⁺ cell tumor infiltration was significantly increased. |
| References |
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| Molecular Formula |
C32H34CLN9O3
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|---|---|
| Molecular Weight |
628.12
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| CAS # |
3005272-36-3
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| Appearance |
White to off-white solid
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| SMILES |
C[C@@H]1CN(CC[C@H]1NC2=CC=C3C(N(N=C3C4CCC(NC4=O)=O)C)=C2)C5=NC=C(C(NC6=CC7=C(N(C(C7)=O)C)C=C6)=N5)Cl
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~159.21 mM; with sonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (3.98 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you canAdd 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of physiological saline: Dissolve 0.9 g of sodium chloride in double-distilled water and dilute to 100 mL to obtain clear physiological saline. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (3.98 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you canAdd 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5921 mL | 7.9603 mL | 15.9205 mL | |
| 5 mM | 0.3184 mL | 1.5921 mL | 3.1841 mL | |
| 10 mM | 0.1592 mL | 0.7960 mL | 1.5921 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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