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(E)-2-Octenal

Alias: trans-2-Octenal
Cat No.:V121734 Purity: ≥98%
(E)-2-Octenal is an antifungal agent.
(E)-2-Octenal
(E)-2-Octenal Chemical Structure CAS No.: 2548-87-0
Product category: Pyruvate Kinase
This product is for research use only, not for human use. We do not sell to patients.
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Product Description
(E)-2-Octenal is an antifungal agent. It disrupts cell membrane integrity and leads to the accumulation of reactive oxygen species (ROS). It reduces the activity of phosphofructokinase and pyruvate kinase. It inhibits the growth of *Neofusicoccum parvum* by interfering with mitochondrial energy metabolism. It also inhibits the growth of *Penicillium italicum* strains resistant to prochloraz. (E)-2-Octenal exhibits broad-spectrum and potent inhibitory activity against a variety of fungi, including *Sclerotium rolfsii*, *Metarhizium anisopliae sensu lato*, and *Aspergillus flavus*. (E)-2-Octenal can be used in research on *Penicillium* disease in citrus and stem rot in mangoes.
Biological Activity I Assay Protocols (From Reference)
ln Vitro
(E)-2-octenal (0.25-2.00 mL L−1; 2-4 days) inhibited the mycelial growth of propanil-resistant Penicillium italicum strain XX5, with a minimum inhibitory concentration (MIC) of 0.25 mL L−1 and a minimum fungicide concentration (MFC) of 0.50 mL L−1 [1]. (E)-2-octenal (1/2 MIC-MIC; 30-120 min) induced dose- and time-dependent oxidative stress in the mycelia of propanil-resistant Penicillium italicum strain XX5, leading to the accumulation of reactive oxygen species (ROS) and lipid peroxidation [1]. (E)-2-octenal (0.1-1.6 μL/mL; 1-4 days) inhibited the mycelial growth of Fusarium neocarpa in a concentration-dependent manner, with a minimum inhibitory concentration (MIC) of 0.4 μL/mL and a minimum fungicide concentration (MFC) of 0.8 μL/mL [2]. (E)-2-octenal (0.2-0.4 μL/mL) can damage the morphology of Fusarium pyrenoidosa hyphae, and the higher the concentration, the more severe the damage [2].
References

[1]. (E)-2-Octenal suppresses the growth of a prochloraz-resistant Penicillium italicum strain and its potential antifungal mechanisms[J]. Postharvest Biology and Technology, 2023, 205: 112515.

[2]. (E)-2-Octenal inhibits Neofusicoccum parvum growth by disrupting mitochondrial energy metabolism and is a potential preservative for postharvest mango. Food Res Int. 2025;201:115639.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C8H14O
Molecular Weight
126.20
CAS #
2548-87-0
Related CAS #
(E)-2-Octenal-d2
Appearance
Liquid (Density: 0.846 g/cm3)
SMILES
CCCCC/C=C/C=O
Synonyms
trans-2-Octenal
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: 请将本产品存放在密封且受保护的环境中(例如氮气下),避免暴露在潮湿环境中。
Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO : ≥ 200 mg/mL (~1584.79 mM)
Solubility (In Vivo)
Solubility in Formulation 1: ≥ 5 mg/mL (39.62 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you canAdd 100 μL of DMSO stock solution (50.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of physiological saline: Dissolve 0.9 g of sodium chloride in double-distilled water and dilute to 100 mL to obtain clear physiological saline.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.

Solubility in Formulation 2: ≥ 5 mg/mL (39.62 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you canAdd 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD saline (4°C, store for one week): Dissolve 2 g of SBE-β-CD powder in 10 mL of saline until completely dissolved and clear.
Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.

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Solubility in Formulation 3: ≥ 5 mg/mL (39.62 mM)(saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you canAdd 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of corn oil and mix well.


 (Please use freshly prepared in vivo formulations for optimal results.)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 7.9239 mL 39.6197 mL 79.2393 mL
5 mM 1.5848 mL 7.9239 mL 15.8479 mL
10 mM 0.7924 mL 3.9620 mL 7.9239 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:
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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

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