| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
|
||
| Other Sizes |
| ln Vitro |
EVT0185 inhibits adipogenesis in hepatocytes with an IC50 value of 0.46 μM[1].
|
|---|---|
| ln Vivo |
EVT0185 (30-100 mg/kg, administered by gavage for 1 month) can reduce tumor burden in the MASH-HCC model [1].
|
| Animal Protocol |
Animal/Disease Models: Metabolic dysfunction-associated steatohepatitis (MASH)-driven hepatocellular carcinoma (HCC) mice models[1]
Doses: 30 and 100 mg/kg Route of Administration: Orally gavaged, 1 month Experimental Results: Reduced tumor numbers in liver. Reduced tumour surface area and lipid accumulation. Elevated levels of AFP. Increased B cells and B cell chemoattractant CXCL13 levels. Increased cleaved caspase 3 levels and reduced Ki67 levels. |
| References |
| Molecular Formula |
C22H34O4
|
|---|---|
| Molecular Weight |
362.50
|
| CAS # |
2588489-03-4
|
| Appearance |
White to off-white solid powder
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~275.86 mM; with sonication)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (6.90 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one)),clear solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can Add 100 μL of 25.0 mg/mL clarified DMSO stock solution to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7586 mL | 13.7931 mL | 27.5862 mL | |
| 5 mM | 0.5517 mL | 2.7586 mL | 5.5172 mL | |
| 10 mM | 0.2759 mL | 1.3793 mL | 2.7586 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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