| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
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| Targets |
Microbial Metabolite Human Endogenous Metabolite
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|---|---|
| ln Vitro |
(R)-3-Hydroxybutanoic acid sodium is a metabolite derived from acetoacetate. Enhanced fatty acid oxidation in the liver leads to increased production of acetoacetate, which is then converted to (R)-3-Hydroxybutanoic acid sodium via a reaction catalyzed by 3-hydroxybutyrate dehydrogenase[1].
|
| References |
| Molecular Formula |
C4H7NAO3
|
|---|---|
| Molecular Weight |
126.09
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| CAS # |
13613-65-5
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| Related CAS # |
(R)-3-Hydroxybutanoic acid-13C2 sodium;202114-54-3;(R)-3-Hydroxybutanoic acid-13C4 sodium;2483735-72-2;(R)-3-Hydroxybutanoic acid,3-Hydroxybutanoic acid-13C sodium;(R)-3-Hydroxybutanoic acid-d3 sodium;(R)-3-Hydroxybutanoic acid (sodium) (Standard);13613-65-5
|
| Appearance |
White to off-white solid powder
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| SMILES |
[Na+].O([H])[C@]([H])(C([H])([H])[H])C([H])([H])C(=O)[O-]
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| Synonyms |
(R)-(-)-3-Hydroxybutanoic acid sodium salt; (R)-(-)-3-Hydroxybutyric acid sodium
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~793.08 mM; with ultrasonication)
DMSO : ~50 mg/mL (~396.54 mM; with ultrasonication (<60°C)) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (19.83 mM)(saturation unknown) in 10% DMSO 40% PEG300 5% Tween-80 45% Saline (add these co-solvents sequentially from left to right, and one by one),clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution and add it to 400 μL PEG300, mix well; then add 50 μL Tween-80 to the above system, mix well; then continue to add 450 μL of normal saline to make up to 1 mL. Preparation of normal saline: Dissolve 0.9 g of sodium chloride in ddH₂O and make up to 100 mL to obtain a clear and transparent normal saline solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (19.83 mM)(saturation unknown) in 10% DMSO 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution and add it to 900 μL of 20% SBE-β-CD saline solution and mix well. 2 g SBE-β-CD (sulfobutyl ether β-cyclodextrin) powder is diluted to 10 mL of saline and completely dissolved until clear and transparent. Solubility in Formulation 3: ≥ 2.5 mg/mL (19.83 mM)(saturation unknown) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution and add it to 900 μL corn oil and mix well. Solubility in Formulation 4: 100 mg/mL (793.08 mM) in PBS (add these co-solvents sequentially from left to right, and one by one),clear solution; with sonication. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.9308 mL | 39.6542 mL | 79.3084 mL | |
| 5 mM | 1.5862 mL | 7.9308 mL | 15.8617 mL | |
| 10 mM | 0.7931 mL | 3.9654 mL | 7.9308 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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